Gestational changes in l-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle

Izumi, Hidetaka; Yallampalli, Chandra; Garfield, Robert E.

doi:10.1016/0002-9378(93)90301-x

Cited by 143 publications

(68 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been reported that high levels of NO production in the myometrium during mid-gestation play a role in maintaining pregnancy by inhibiting uterine smooth muscle constriction, 16,17) and the findings of present study correlate well with these reports. In addition, the present study indicates that the decidua is a major region of uterine NO production.…”

Section: Resultssupporting

confidence: 91%

Changes in Nitric Oxide Production Levels and Expression of Nitric Oxide Synthase Isoforms in the Rat Uterus during Pregnancy

Suzuki

Mori

Yoshikawa

et al. 2009

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 91%

Changes in Nitric Oxide Production Levels and Expression of Nitric Oxide Synthase Isoforms in the Rat Uterus during Pregnancy

Suzuki

Mori

Yoshikawa

et al. 2009

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

“…Furthermore, since preeclampsia is a very heterogeneous disease, it may be critical to focus therapeutic studies with sildenafil specifically in subgroups of patients who have augmented circulating sFLT1 and increased pressor response to Ang II. In normal pregnancy, despite enhanced Ang II and volume expansion, NO production is amplified (21,(43)(44)(45)(46)(47), likely by growth factors such as VEGF and placental growth factor that are required for normal placental angiogenesis (24,25,48). The actions of NO to reduce blood pressure during pregnancy are pleiotropic, primarily through endothelium-dependent dilation and resulting smooth muscle relaxation, which decreases vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia

Burke¹,

Zsengellér²,

Khankin³

et al. 2016

Journal of Clinical Investigation

123

101

View full text Add to dashboard Cite

“…Recent studies have shown that adrenomedullin might modulate vascular tone as a paracrine regulator, through the inhibition and/or stimulation of vasoactive agents such as nitric oxide (19) and ET-1 (20), produced by feto-placental tissues, which have been demonstrated to regulate placental circulation (21,22). Furthermore both these agents are involved in the control of myometrial contractility (23,24), and a preliminary study has shown that adrenomedullin exerts an inhibitory effect upon the contractile response of rat uterine muscle to galanin (25), suggesting that adrenomedullin, directly through the cAMP or indirectly through the regulation of other modulators, could also affect uterine contractility.…”

Section: Discussionmentioning

confidence: 99%

Adrenomedullin production is increased in normal human pregnancy

Iorio¹,

Marinoni²,

Letizia

et al. 1999

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Adrenomedullin, a recently discovered vasoactive peptide originally identified in pheochromocytoma, has been found to be increased in the plasma of pregnant women at term. This study was designed to elucidate whether adrenomedullin secretion is dependent on gestational age and the possible source and function of this peptide in human pregnancy. Study design: Adrenomedullin concentrations were determined by RIA in amniotic fluid and maternal plasma obtained from 110 pregnant women between 8 and 40 weeks of gestation. Subjects were stratified into five groups according to gestational age. In term patients (n¼15), adrenomedullin was also measured in the umbilical artery and vein separately. Results: High concentrations of adrenomedullin were present in plasma and amniotic fluid samples from patients in the first, second and third trimester. There was no significant difference in mean maternal plasma concentration of adrenomedullin between the five patient groupings. Amniotic fluid adrenomedullin concentrations decreased from 81.2Ϯ11.7 pg/ml at 8-12 weeks of gestation to 63.7Ϯ6.0 pg/ml at 13-20 weeks of gestation and then increased at 21-28 weeks of gestation to 99.1Ϯ10.4 pg/ml. A further increase was found in samples collected after 37 weeks of gestation (132.6Ϯ10.1 pg/ml). In the umbilical vein, adrenomedullin concentration was higher (P<0.05) than in the artery (65.7Ϯ6.1 pg/ml and 48.5Ϯ5.2 pg/ml respectively), suggesting that adrenomedullin in the fetal circulation derives from the placenta.Conclusions: Our results demonstrate the presence of adrenomedullin in maternal plasma and amniotic fluid throughout gestation, and show that its production starts very early in gestation, suggesting that this hormone may have an important role in human reproduction, from implantation to delivery.

show abstract

Gestational changes in l-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle

Cited by 143 publications

References 17 publications

Changes in Nitric Oxide Production Levels and Expression of Nitric Oxide Synthase Isoforms in the Rat Uterus during Pregnancy

Changes in Nitric Oxide Production Levels and Expression of Nitric Oxide Synthase Isoforms in the Rat Uterus during Pregnancy

Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia

Adrenomedullin production is increased in normal human pregnancy

Contact Info

Product

Resources

About