“…Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is the rate-limiting enzyme in the formation of mevalonate [14]. Mevalonate is a precursor of farnesyl pyrophosphate and geranylgeranyl pyrophosphate (GGPP), which are critical components in protein isoprenylation of small regulatory G proteins of the Ras-homologous (Rho) family 4 [15]. Proteins of Rho family are required for a broad range of cellular functions, including membrane trafficking, cytoskeletal organization, growth, apoptosis, and differentiation [16].…”