The Vangtat deposit is the major gold deposit in a new orogenic gold belt discovered and developed in southeastern Laos in the past two decades. Our study of the Vangtat orogenic gold deposit shows that it formed within a convergent margin along the western segment of the Poko suture zone, which marks the collision between the Indochina Terrane and the Kontum Massif. Shear structure and greenschist facies metamorphic rocks are the main hosts for gold mineralization in the Vangtat deposit. High-grade gold-bearing quartz-sulfide veins and wall rock hydrothermal alteration are genetically related, and alteration minerals consist of quartz, carbonate, graphite, white mica, chlorite, and pyrite. The study of fluid inclusions and wall rock alteration assemblages indicate that the Vangtat gold deposit was formed by an aqueous-carbonic, low salinity, reduced, weakly alkaline to near-neutral pH fluid, mainly composed