2016
DOI: 10.1186/s13071-016-1918-2
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Abstract: BackgroundThe evolutionary history and ecological associations of Trypanosoma cruzi, the need to identify genetic markers that can distinguish parasite subpopulations, and understanding the parasite’s evolutionary and selective processes have been the subject of a significant number of publications since 1998, the year when the first DNA sequence analysis for the species was published.MethodsThe current analysis systematizes and re-analyzes this original research, focusing on critical methodological and analyt… Show more

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Cited by 33 publications
(28 citation statements)
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References 141 publications
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“…The same genetic variant of the T. cruzi parasite, the TcI lineage, was observed in both vectors and dogs in Getsemaní community, which agrees with previous studies that reports this lineage to be the most common in Central America (Zuriaga et al, 2012;Dorn et al, 2017). The finding of TcI in sympatric vectors and in dogs needs further studies in order to identify genotypic differences using more appropriate gene markers and assays with better sensitivity that could contribute to elucidate population dynamics (Izeta-Alberdi et al, 2016).…”
Section: Discussionsupporting
confidence: 88%
“…The same genetic variant of the T. cruzi parasite, the TcI lineage, was observed in both vectors and dogs in Getsemaní community, which agrees with previous studies that reports this lineage to be the most common in Central America (Zuriaga et al, 2012;Dorn et al, 2017). The finding of TcI in sympatric vectors and in dogs needs further studies in order to identify genotypic differences using more appropriate gene markers and assays with better sensitivity that could contribute to elucidate population dynamics (Izeta-Alberdi et al, 2016).…”
Section: Discussionsupporting
confidence: 88%
“…Importantly, we amplified directly from T . dimidiata abdominal DNA, therefore avoiding the biases resulting from culturing isolates prior to sequencing [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…periods has yet to be assessed, present results indicate that there is a biogeographic region association with triatomine-mammal interactions that depends on the specific community structure, connected by synanthropic species (Izeta-Alberdi et al 2016). Some species´ groups associated with anthropozoonotic diseases have adapted to be almost completely synanthropic, such as dengue (Lambrechts et al 2010), or partially synanthropic, such as American trypanosomiasis (Gaunt and Miles 2000).…”
Section: Discussionmentioning
confidence: 80%
“…The Kinetplastid, Trypanosoma cruzi (Trypanosomatidae) is an obligate parasite that alternates between invertebrates (kissing bugs belonging to the family Reduviidae) and terrestrial mammals. It has low species-host specificity along its geographic range in the American continent (Izeta- Alberdi et al 2016), which may be explained by intrinsic factors related to sophisticated host defense response mechanisms (Freire- de-Lima et al 2012;Caballero et al 2015) and to extrinsic factors that ensure persistence and transmission in vector-host PeerJ reviewing PDF | (2016:09:13149:1:1:REVIEW 8 Feb 2017)…”
Section: Introductionmentioning
confidence: 99%
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