Gentians, natural remedies for future of visceral pain control; an ethnopharmacological review with an in silico approach

Pasdaran, Ardalan; Butovska, Daniela; Kerr, Philip G.; Naychov, Zheko; Aneva, Ina; Kozuharova, Ekaterina

doi:10.1007/s42977-022-00114-7

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…Anthocyanins are flavonoid derivatives formed by anthocyanidins with a core structure of 3, 5, 7‐trihydroxyl‐2‐phenylbenzo‐pyran cations and aglycones at the C3 site via glycosidic bonds [80] . They exhibited a wide range of biological activities and health‐promoting benefits, including immunomodulatory, antioxidant, anti‐inflammatory, anti‐aging, lowering lipid, anti‐cancer, and neuroprotection [80–84] . Anthocyanins have also been shown to lower insulin resistance in diabetic patients.…”

Section: Resultsmentioning

confidence: 99%

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

Mehrzadeh,

Ziayeezadeh,

Pasdaran

et al. 2024

Chemistry & Biodiversity

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A comprehensive literature search was conducted in PubMed, Cochrane Library, Web of Science, Scopus, the National Library of Medicine (NLM) catalog, and Google Scholar from January 1980 up until October 2023 on plants in the Gundelia genus. Gundelia L. (Asteraceae) has been treated as a monospecific genus with G. tournefortii L. (1753: 814) in most recent floras with wide variation in corolla color, but nowadays, the genus consists of 17 species. The unripe inflorescences of these species, especially Gundelia tournefortii L., are consumed in many ways. 'Akkoub' or 'akko' in Arabic, “Kangar” in Persian, and “Silifa” in Greek are the common names of G. tournefortii L., also known as tumble thistle in English. They have been used in traditional medicine to treat bronchitis, kidney stones, diarrhea, stomach pain, inflammation, liver and blood diseases, bacterial and fungal infections, and mumps. Based on recent studies, their extracts have exhibited hepatoprotective, hypolipidemic, antioxidant, anti‐inflammatory, and antimicrobial effects. Moreover, a variety of phytochemicals, including terpenoids, sterols, and fatty acids, as well as vitamins and minerals, have been identified in this genus. This study reviewed the ethnobotany, phytochemicals, and biological activities of the plants in the Gundelia genus as functional foods and herbal remedies.

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Section: Resultsmentioning

confidence: 99%

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

Mehrzadeh,

Ziayeezadeh,

Pasdaran

et al. 2024

Chemistry & Biodiversity

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“…Gentiana spp. have been used to control visceral pain [65,66,341]. Gentiana macrophylla root has been used in TCM to treat inflammation and pain and systemic lupus erythematosus [239].…”

Section: Toxicity and Side Effectsmentioning

confidence: 99%

A Review of the Potential Benefits of Herbal Medicines, Small Molecules of Natural Sources, and Supplements for Health Promotion in Lupus Conditions

Pasdaran

Hassani

Tavakoli

et al. 2023

Life

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The Latin word lupus, meaning wolf, was in the medical literature prior to the 1200s to describe skin lesions that devour flesh, and the resources available to physicians to help people were limited. The present text reviews the ethnobotanical and pharmacological aspects of medicinal plants and purified molecules from natural sources with efficacy against lupus conditions. Among these molecules are artemisinin and its derivatives, antroquinonol, baicalin, curcumin, emodin, mangiferin, salvianolic acid A, triptolide, the total glycosides of paeony (TGP), and other supplements such as fatty acids and vitamins. In addition, medicinal plants, herbal remedies, mushrooms, and fungi that have been investigated for their effects on different lupus conditions through clinical trials, in vivo, in vitro, or in silico studies are reviewed. A special emphasis was placed on clinical trials, active phytochemicals, and their mechanisms of action. This review can be helpful for researchers in designing new goal-oriented studies. It can also help practitioners gain insight into recent updates on supplements that might help patients suffering from lupus conditions.

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Regulatory mechanisms of Gentiopicroside on human diseases: a brief review

Liu,

Pang,

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Gentians, natural remedies for future of visceral pain control; an ethnopharmacological review with an in silico approach

Cited by 6 publications

References 48 publications

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

A Review of the Ethnobotany, Biological Activity, and Phytochemistry of the Plants in the Gundelia Genus

A Review of the Potential Benefits of Herbal Medicines, Small Molecules of Natural Sources, and Supplements for Health Promotion in Lupus Conditions

Regulatory mechanisms of Gentiopicroside on human diseases: a brief review

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