Genotypic and Phenotypic Analyses of Hepatitis C Virus from Patients Treated with JTK-853 in a Three-Day Monotherapy

Ogura, Naoto; Toyonaga, Yukiyo; Ando, Izuru; Hirahara, Kunihiro; Shibata, Tsutomu; Turcanu, Gabriela; Pai, Sudhakar M.; Yee, Kan; Gerhardt, Barbara; Rodrı́guez-Torres, Maribel; Noguchi, Tōru

doi:10.1128/aac.01432-12

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“…Two major resistant variants (Leu414 and Ile423) and seven minor variants (Asn316, Val421, Phe445, Leu482, Ala494, Ala499 and Gly556) were found as natural polymorphs in selected genotypes. [105][106][107] Specifically, Leu414 and Ile423 were found in 36.8% of the HCV genotype 4 and in all HCV genotype 5 sequences, respectively. 108 2.5.4 Phenotypic resistance to directly acting antiviral agents.…”

Section: Hbvmentioning

confidence: 96%