Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg Polymorphism of the β3-Adrenergic Receptor Is Associated With Type 2 Diabetes and Obesity in a Large Japanese Sample

Oizumi, Toshihide; Daimon, Makoto; Saitoh, Tamotsu; Kameda, Wataru; Yamaguchi, Hiroshi; Ohnuma, Hiroshi; Inamori, Masahiko; Eguchi, Hideyuki; Manaka, Hideo; Tominaga, Makoto; Kato, Takeshi

doi:10.2337/diacare.24.9.1579

Cited by 67 publications

(44 citation statements)

References 32 publications

(19 reference statements)

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“…24 In previous epidemiologic studies, the association between the ADRB3 variant and obesity-related phenotypes has been investigated among individuals from several racial/ ethnic groups and nationalities, including Caucasians, 13 Japanese, 12,25,26 Pima Indians, 24 Mexican Americans, 14 African Americans 27,28 and Jamaicans. 29 Previous studies of white or Japanese populations found the variant allele of the ADRB3 receptor to be associated with elevated measures of obesity, 13 whereas two previous studies of African Americans reported associations with the wild-type receptor.…”

Section: Adrb3 and Obesity R Mckean-cowdin Et Almentioning

confidence: 99%

“…11 The ADRB3 gene is highly conserved between humans and rodents and its functional impairment may lead to obesity by altering metabolic processes of fat tissue. 11,12 The receptor is expressed in visceral and subcutaneous fat tissue, but is more abundant and active in visceral tissue. 11 A missense change at codon 64 of this gene (Trp64Arg) has been identified and has been associated with measures of obesity, [12][13][14] weight gain, 15 insulin resistance 13 and type II diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 The receptor is expressed in visceral and subcutaneous fat tissue, but is more abundant and active in visceral tissue. 11 A missense change at codon 64 of this gene (Trp64Arg) has been identified and has been associated with measures of obesity, [12][13][14] weight gain, 15 insulin resistance 13 and type II diabetes. 12 In the current study, we examined the association between the codon 64 ADRB3 missense change and measures of weight and obesity among African-American breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

“…11 A missense change at codon 64 of this gene (Trp64Arg) has been identified and has been associated with measures of obesity, [12][13][14] weight gain, 15 insulin resistance 13 and type II diabetes. 12 In the current study, we examined the association between the codon 64 ADRB3 missense change and measures of weight and obesity among African-American breast cancer patients. We assessed the relationship of the ADRB3 genotypes with visceral and subcutaneous abdominal fat, body mass index (BMI), weight change and measures of central obesity (waist, hip, waist-to-hip ratio (WHR)) approximately 30 months after diagnosis of breast cancer, when most women had finished their primary cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

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The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases

McKean‐Cowdin

Bernstein

et al. 2007

Int J Obes

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Objective: To determine if a missense change at codon 64 of ADRB3 (Trp64Arg), a candidate obesity gene, is associated with obesity and levels of subcutaneous or visceral fat in African-American breast cancer cases. Several observational studies have found that women, who are overweight or obese at the time of diagnosis, as well as those who gain weight after diagnosis, are at greater risk for breast cancer recurrence and death than non-overweight women. Design: Prospective cohort of breast cancer cases. Subjects: 219 African-American breast cancer patients participating in the Los Angeles component of the Health, Eating, Activity and Lifestyle Study. Measures: ADRB3 Trp64Arg genotype, measures of weight including body mass index (BMI), weight gain (weight 5 years before diagnosis compared with weight at 30 months after diagnosis), obesity (BMIX30 kg/m 2 ), waist/hip circumference and visceral or subcutaneous fat were determined by magnetic resonance imaging. Results: African-American women who were homozygous for the ADRB3 wild-type allele had significantly higher mean visceral fat levels than women who carried the variant (P ¼ 0.04), and were significantly more likely to be obese (odd ratios (OR) ¼ 2.1, 95% confidence interval (CI) ¼ 1.1-4.2). The association with obesity was most pronounced among women who were premenopausal (OR ¼ 4.8, 95% CI ¼ 1.3-18), who received chemotherapy for their breast cancer (OR ¼ 6.1, 95% CI ¼ 1.8-20), or who were not physically active (OR ¼ 3.9, 95% CI ¼ 1.5-9.7). Conclusion: The wild-type allele of the ADRB3 missense change was associated with measures of obesity in our sample of African-American women. The association was modified by menopausal status, history of chemotherapy and modest levels of physical activity. These results will need to be confirmed in an independent sample.

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Section: Adrb3 and Obesity R Mckean-cowdin Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases

McKean‐Cowdin

Bernstein

et al. 2007

Int J Obes

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show abstract

“…Two polymorphisms in the β2-adrenergic receptors (arginine/glycine substitution, Arg16Gly; and glutamine/ glutamate substitution, Gln27Glu) of the β2-adrenoceptor gene were studied (6,7). One polymorphism (tryptophan/ arginine substitution, Trp64Arg) of the β3-adrenoceptor gene was also studied (10).…”

Section: Genotypingmentioning

confidence: 99%