Genotoxicity testing of a fenugreek extract

Flammang, A.M.; Cifone, Maria A.; Erexson, Gregory L.; Stankowski, Leon F.

doi:10.1016/j.fct.2004.07.003

Cited by 82 publications

(53 citation statements)

References 8 publications

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“…The mouse sperm morphology assay, has been used to characterize mutagenic properties of a wide variety of chemicals (Bruce and Wyrobek, 1974;Wyrobek et al, 1983). Special Foodstuff formulated for people with diabetes, containing fenugreek extract with 40% 4-hydroxyisoleucine, was earlier found to possess no genotoxic properties (Muralidhara et al, 1999;Flamming et al, 2004;Dixit et al, 2008). However, the damage induced in the sperm morphology during the current study, reflected genetic damage in the male germ cells, either due to small deletions or point mutations (Bruce and Wyrobek, 1974;Wyrobek et al, 1983), or protein abnormality (Brinkworth et al, 1987;Flamming et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Al-Ashban¹,

Abou‐Shaaban²,

Shah³

2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYAcute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.

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Section: Discussionmentioning

confidence: 99%

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Al-Ashban¹,

Abou‐Shaaban²,

Shah³

2010

Oriental Pharmacy and Experimental Medicine

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“…This may be due to the presence of sapogenins, which increase biliary cholesterol excretion, resulting in reduced serum cholesterol levels [84,85]. The U.S. Food and Drug Administration, with regard to food ingredients, has determined that fenugreek seed extracts are not genotoxic (based on a minimum content of 40% 4-OHIle) [86].…”

Section: Fenugreek (Trigonella Foenum-graecum L)mentioning

confidence: 99%

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Avalos-Soriano

Cruz-Cordero²,

Rosado

et al. 2016

Molecules

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Obesity and insulin resistance (IR) are interdependent multifactorial processes that cannot be understood separately. Obesity leads to systemic inflammation and increased levels of free fatty acids that provoke IR and lipotoxicity. At the same time, IR exacerbates adipose cell dysfunction, resulting in chronic inflammation and major lipotoxic effects on nonadipose tissues. 4-Hydroxyisoleucine (4-OHIle), a peculiar nonprotein amino acid isolated from fenugreek (Trigonella foenum-graecum) seeds, exhibits interesting effects on IR related to obesity. 4-OHIle increases glucose-induced insulin release, and the insulin response mediated by 4-OHIle depends on glucose concentration. The beneficial effects observed are related to the regulation of blood glucose, plasma triglycerides, total cholesterol, free fatty acid levels, and the improvement of liver function. The mechanism of action is related to increased Akt phosphorylation and reduced activation of Jun N-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-κB. Here, we present a review of the research regarding the insulinotropic and insulin-sensitising activity of 4-OHIle in in vitro and in vivo models.

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“…Fenugreek (Trigonella foenumgraecum L.) is an annual herb belonging to Legume family; it is widely grown in India, Egypt, and Middle Eastern countries [35]. It used both in medicine and with food as spice show antioxidant effect through their use in diabetes mellitus due to the presence of different active constituents such as flavonoids, alkaloids, vitamins and amino acids [36].…”

Section: Fenugreek (Trigonella Foenumgraecum L)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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Genotoxicity testing of a fenugreek extract

Cited by 82 publications

References 8 publications

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

Prevention of Nephropathy by Some Natural Sources of Antioxidants

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