Genotoxicity, potential cytotoxicity and cell uptake of titanium dioxide nanoparticles in the marine fish Trachinotus carolinus (Linnaeus, 1766)

Overview of the toxic effects of titanium dioxide nanoparticles in blood, liver, muscles, and brain of a Neotropical detritivorous fish

“…The lack of evidence of DNA damage in RBC was probably due to a high RBC hemolysis that might have occurred in P. lineatus exposed to TiO 2 ‐NP. Other studies in fish showed that acute exposure to TiO 2 ‐NP resulted in DNA damage, formation of MN and ENAs, and decreased erythrocyte viability . In these studies, however, the oxidative and genotoxic potential of TiO 2 ‐NP was enhanced by ultraviolet light, a factor that was absent in this study.…”

“…In freshwater Teleostei, TiO 2 ‐NP are likely absorbed through the gills during the respiratory process and/or through the intestine via diet, and from these organs, they may reach the blood stream. Once in the blood, TiO 2 ‐NP may cause genotoxic damage to erythrocytes (formation of micronuclei and nuclear abnormalities) as it was found in marine fish . In freshwater fish, a reduction of red blood cells, hemoglobin content, and white blood cells were found after TiO 2 ‐NP exposure .…”

Genomic and chromosomal damage in the marine mussel Mytilus galloprovincialis: Effects of the combined exposure to titanium dioxide nanoparticles and cadmium chloride

“…The capacity of n-TiO 2 to induce chromosomal alteration has been previously reported in the marine fish Dicentrarchus labrax, where a six time increase of micronucleated cell frequency was observed (Della Torre et al, 2015b;Nigro et al, submitted) and in T. carolinus (Vignardi et al, 2015). Moreover, both in mussel (present paper) and sea bass (Nigro et al, submitted), lower MN frequency after n-TiO 2 /CdCl 2 co-exposure was observed.…”

Combination effects of nano-TiO2 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on biotransformation gene expression in the liver of European sea bass Dicentrarchus labrax

“…At level of organ and whole organism, physiological, reproductive and behavioral alterations as well as developmental defects have been also documented (Baker et al, 2014;Minetto et al, 2014). However, up to now, few contributions have investigated sub-lethal effects of nano-TiO 2 in marine fish species (Min-Kyeong and Hyo-Eun, 2010;Paterson et al, 2011;Della Torre et al, 2015a;Vignardi et al, 2015).…”