Genotoxicity of the phosphoramidate agent tabun (GA)

The Long Term Changes in Liver DNA and Total Protein Contents Following Low Level Sarin Exposure in Rats

“…OP agent tabun was described as weakly acting mutagen using Salmonella spp. assays with S-9 and mouse lymphoma cells (19). A significant decrease in DNA synthesis in isolated hepatocytes following soman exposure in vitro was also shown (8).…”

“…Male albino SPF rats weighing 180-220g were purchased from Konárovice (Czech Republic). They were kept in 19 ORIGINAL ARTICLE Summary: 1. The changes in contents of DNA and total protein in the liver of the rats exposed to low level sarin by inhalation at 3, 6 and 12 months following the exposure were studied.…”

The Long Term Changes in Liver DNA and Total Protein Contents Following Low Level Sarin Exposure in Rats

“…OP agent tabun was described as weakly acting mutagen using Salmonella spp. assays with S-9 and mouse lymphoma cells (19). A significant decrease in DNA synthesis in isolated hepatocytes following soman exposure in vitro was also shown (8).…”

“…Male albino SPF rats weighing 180-220g were purchased from Konárovice (Czech Republic). They were kept in 19 ORIGINAL ARTICLE Summary: 1. The changes in contents of DNA and total protein in the liver of the rats exposed to low level sarin by inhalation at 3, 6 and 12 months following the exposure were studied.…”

Organophosphate Nerve Agents

“…Neither agent GB nor agent VX was genotoxic in a series of microbial and mammalian assays (Crook et al, 1983;Goldman et al, 1987Goldman et al, , 1988, whereas agent GA has been reported to be weakly mutagenic in similar cellular assays (Wilson et al, 1994). Experimental results indicate that agents GB, GA, and VX have no carcinogenic potential (Weimer et al, 1979;Goldman et al, 1988;Bucci et al, 1992a,b).…”

Appendix A: Health Risk Assessment for the Nerve Agent Ga

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The Long Term Changes in Liver DNA and Total Protein Contents Following Low Level Sarin Exposure in Rats

“…OP agent tabun was described as weakly acting mutagen using Salmonella spp. assays with S-9 and mouse lymphoma cells (19). A significant decrease in DNA synthesis in isolated hepatocytes following soman exposure in vitro was also shown (8).…”

“…Male albino SPF rats weighing 180-220g were purchased from Konárovice (Czech Republic). They were kept in 19 ORIGINAL ARTICLE Summary: 1. The changes in contents of DNA and total protein in the liver of the rats exposed to low level sarin by inhalation at 3, 6 and 12 months following the exposure were studied.…”

Organophosphate Nerve Agents

“…Neither agent GB nor agent VX was genotoxic in a series of microbial and mammalian assays (Crook et al, 1983;Goldman et al, 1987Goldman et al, , 1988, whereas agent GA has been reported to be weakly mutagenic in similar cellular assays (Wilson et al, 1994). Experimental results indicate that agents GB, GA, and VX have no carcinogenic potential (Weimer et al, 1979;Goldman et al, 1988;Bucci et al, 1992a,b).…”

Appendix A: Health Risk Assessment for the Nerve Agent Ga

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The Long Term Changes in Liver DNA and Total Protein Contents Following Low Level Sarin Exposure in Rats

“…OP agent tabun was described as weakly acting mutagen using Salmonella spp. assays with S-9 and mouse lymphoma cells (19). A significant decrease in DNA synthesis in isolated hepatocytes following soman exposure in vitro was also shown (8).…”

“…Male albino SPF rats weighing 180-220g were purchased from Konárovice (Czech Republic). They were kept in 19 ORIGINAL ARTICLE Summary: 1. The changes in contents of DNA and total protein in the liver of the rats exposed to low level sarin by inhalation at 3, 6 and 12 months following the exposure were studied.…”

Organophosphate Nerve Agents

“…Neither agent GB nor agent VX was genotoxic in a series of microbial and mammalian assays (Crook et al, 1983;Goldman et al, 1987Goldman et al, , 1988, whereas agent GA has been reported to be weakly mutagenic in similar cellular assays (Wilson et al, 1994). Experimental results indicate that agents GB, GA, and VX have no carcinogenic potential (Weimer et al, 1979;Goldman et al, 1988;Bucci et al, 1992a,b).…”

Appendix A: Health Risk Assessment for the Nerve Agent Ga

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