2011
DOI: 10.1002/mnfr.201000509
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Abstract: Topoisomerase II-mediated DNA damage appears related to the prolongation of enzyme DNA residence more than to enzyme-DNA cleavage. Due to this reason, genistein and other tested natural and dietary Topo II poisons have a much lower genotoxic potential than therapeutic ones under the conditions of equal topoisomerase II-DNA linkage.

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Cited by 27 publications
(29 citation statements)
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References 68 publications
(152 reference statements)
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“…8-HO-DAI showed inhibitory properties at concentrations exceeding 100 M, and the enzyme was completely blocked at 250 M (Fig. 3A, lane [16][17]. Comparable results were obtained with recombinant topoisomerase II␣ (Fig.…”
Section: Cell-free Screening Of the Effects Of Dai And Its Oxidative mentioning
confidence: 74%
“…8-HO-DAI showed inhibitory properties at concentrations exceeding 100 M, and the enzyme was completely blocked at 250 M (Fig. 3A, lane [16][17]. Comparable results were obtained with recombinant topoisomerase II␣ (Fig.…”
Section: Cell-free Screening Of the Effects Of Dai And Its Oxidative mentioning
confidence: 74%
“…Bearing this in mind, it is tempting to speculate that it is a so far poorly appreciated nuclear function of Rac1 that is required for stimulation of the DDR following treatment with topo II targeting anticancer drugs. Apart from anticancer drugs, dietary flavanols have also been shown to affect topoisomerase function (62,63). Whether Rac1 signaling is also involved in this process remains to be elucidated.…”
mentioning
confidence: 99%
“…One notable example is genistein, a phytoestrogen with soy and soy‐based products as predominant dietary source. Genistein is well known to interfere with topoisomerases, acting among others as a potent inhibitor of topoisomerase IIbeta (Kalfalah et al, 2011). Another prominent candidate is quercetin, a potent inhibitor of topoisomerase I and IIbeta (Bandele and Osheroff, 2007; Boege et al, 1996), which is present in a multitude of frequently consumed fruits and vegetables, such as nuts, apples and onions.…”
mentioning
confidence: 99%
“…The list includes widely consumed plant polyphenols (Bandele and Osheroff, 2007;Boege et al, 1996;Habermeyer et al, 2005), fungal food contaminants (Fehr et al, 2009), benzoquinone metabolites of therapeutics and industrial chemicals (Bender et al, 2004;Lindsey et al, 2005). These compounds are present in human food and/or the environment and interfere significantly with chromatin interactions of topoisomerase I and/or II (Kalfalah et al, 2011) at concentrations plausibly encountered in the human body during normal life (Nielsen and Williamson, 2007;Ross and Kasum, 2002).…”
mentioning
confidence: 99%
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