“…The list includes widely consumed plant polyphenols (Bandele and Osheroff, 2007;Boege et al, 1996;Habermeyer et al, 2005), fungal food contaminants (Fehr et al, 2009), benzoquinone metabolites of therapeutics and industrial chemicals (Bender et al, 2004;Lindsey et al, 2005). These compounds are present in human food and/or the environment and interfere significantly with chromatin interactions of topoisomerase I and/or II (Kalfalah et al, 2011) at concentrations plausibly encountered in the human body during normal life (Nielsen and Williamson, 2007;Ross and Kasum, 2002).…”