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“…SLC7A11 (xCT) is an anionic amino acid transporter that is highly specific for the amino acids cysteine and glutamate [30]. Increased expression of SLC7A11 at the RNA and protein levels in CDCs has been shown previously [8,11].…”
Section: Discussionmentioning
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“…SLC7A11 (xCT) is an anionic amino acid transporter that is highly specific for the amino acids cysteine and glutamate [30]. Increased expression of SLC7A11 at the RNA and protein levels in CDCs has been shown previously [8,11].…”
Section: Discussionmentioning
“…As previously described, many SLC genes in CDC are dysregulated in comparison to normal tissue samples [8,11]. Therefore, we decided to investigate the expression of SLC genes in more detail.…”
Section: Solute Carrier Genesmentioning
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“…They exhibit different molecular alterations, and therefore a differential response to therapies. The most frequent subtypes are clear cell RCC which comprises 80%, 6 papillary (10%–15%), 7 chromophobe (5%), 8 and collecting duct (1%) 9 . Localized RCC is effectively treated by surgical resection; meanwhile, metastatic RCC (mRCC) is treated with systemic therapies.…”
Section: Introductionmentioning
“…The most frequent subtypes are clear cell RCC which comprises 80%, 6 papillary (10%-15%), 7 chromophobe (5%), 8 and collecting duct (1%). 9 Localized RCC is effectively treated by surgical resection; meanwhile, metastatic RCC (mRCC) is treated with systemic therapies. However, this neoplasia is resistant to conventional chemotherapy and radiotherapy, and current strategies are only palliative.…”
Section: Introductionmentioning