1999
DOI: 10.1038/13802
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Abstract: Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosome amplification, and was accompanied by abnormalities in mitosis, cytokinesis and growth control. Unequal segregation of chromosomes due to multiple spindle poles during mitosis occurred… Show more

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Cited by 457 publications
(389 citation statements)
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“…Targeted disruption of gadd45a, gadd45b or gadd45g resulted in apparently normal murine development without any overt abnormalities, suggesting that gadd45 family members do not play a major role during steady-state hematopoiesis (Hollander et al, 1999;Hoffmeyer et al, 2001;Lu et al, 2004). However, how gadd45 proteins affect the response of hematopoietic cells under stressful conditions remained Here, we show that loss of gadd45 function resulted in compromised differentiation and survival of myeloid progenitor cells upon acute cytokine-driven (i.e.…”
Section: Discussionmentioning
confidence: 81%
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“…Targeted disruption of gadd45a, gadd45b or gadd45g resulted in apparently normal murine development without any overt abnormalities, suggesting that gadd45 family members do not play a major role during steady-state hematopoiesis (Hollander et al, 1999;Hoffmeyer et al, 2001;Lu et al, 2004). However, how gadd45 proteins affect the response of hematopoietic cells under stressful conditions remained Here, we show that loss of gadd45 function resulted in compromised differentiation and survival of myeloid progenitor cells upon acute cytokine-driven (i.e.…”
Section: Discussionmentioning
confidence: 81%
“…Mice genotype was confirmed by PCR using specific primer sets for gadd45a, gadd45b and the neomycin phosphotransferase reporter gene each time the litters were produced (Hollander et al, 1999;Gupta et al, 2005). Femoral BM was prepared from 6-to 8-week-old inbred female gadd45aÀ/À, gadd45bÀ/À and wt littermates.…”
Section: Treatment Of Mice and Bone Marrowmentioning
confidence: 99%
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“…The fact that Gadd45a null mice exhibit genomic instability and increased radiation-induced carcinogenesis [36] implies that several premature aging phenotypes observed in TR4KO mice could result from loss of Gadd45a expression. Although Gadd45a null mice do not have hyper-sensitivity to IR-induced death [36], Gadd45a null hematopoietic cells are sensitive to genotoxic stress-induced apoptosis [37]. Therefore, the importance of GADD45A and whether there are other molecules involved in mediating TR4 protecting against IR-induced cell death demands further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, centrosomal aberrations have been correlated with a number of different genetic abnormalities in tumours, e.g. amplification of STK15 (Zhou et al, 1998), mutations in TP53 (Carroll et al, 1999), and inactivation of BRCA1 (Xu et al, 1999), BRCA2 (Tutt et al, 1999), and GADD45 (Hollander et al, 1999). In adenocarcinomas of the prostate and breast, centrosomal abnormalities are known to increase in parallel to loss of tissue differentiation and the development of aneuploidy (Pihan et al, 2001;Lingle et al, 2002).…”
Section: Discussionmentioning
confidence: 99%