2006
DOI: 10.1016/j.cell.2005.11.044
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Abstract: The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination, genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been identified (SIRT1-SIRT7), and it has been speculated that some may have similar functions to Sir2. Here, we demonstrate that SIRT6 is a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic instability in mouse cells, in association with a role in base excision repair (BER). SIRT6-deficient … Show more

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Cited by 1,393 publications
(1,537 citation statements)
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References 76 publications
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“…We found that SIRT7‐deficient cells had a reduced (~50%) capacity to repopulate the lymphoid compartment compared with WT bone marrow cells (Fig EV1C). Moreover, analysis of primary and peripheral lymphoid organs revealed leukopenia (Fig 2G), as has been reported in other progeroid mouse models including SirT6 −/− mice (Mostoslavsky et al , 2006; Murga et al , 2009). …”
Section: Resultssupporting
confidence: 83%
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“…We found that SIRT7‐deficient cells had a reduced (~50%) capacity to repopulate the lymphoid compartment compared with WT bone marrow cells (Fig EV1C). Moreover, analysis of primary and peripheral lymphoid organs revealed leukopenia (Fig 2G), as has been reported in other progeroid mouse models including SirT6 −/− mice (Mostoslavsky et al , 2006; Murga et al , 2009). …”
Section: Resultssupporting
confidence: 83%
“…Our results indicate a novel function of SIRT7 in both embryonic and postnatal development (Fig 1A and Appendix Fig S1D). Sirtuin deficiency has been previously associated with reduced lifespan; for example, SirT6 −/− mice die within the first month of life with clear signs of accelerated aging (Mostoslavsky et al , 2006). However, only SIRT1 deficiency has been associated with severe developmental defects (Cheng et al , 2003; McBurney et al , 2003; Wang et al , 2008a).…”
Section: Discussionmentioning
confidence: 99%
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“…Constitutive deletion of Sirt6 causes dramatically reduced lifespan in mice accompanied by features of premature aging (Mostoslavsky et al, 2006), implicating proper SIRT6 function in the prevention of tissue aging. In human fibroblasts, SIRT6 deacetylates H3K9ac at telomeric chromatin, and this function is critical for telomere maintenance and prevention of a senescent state (Michishita et al, 2008).…”
Section: Histone Acetylation In Aging Stem Cellsmentioning
confidence: 99%