2020
DOI: 10.1590/0074-02760200521
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Genomic diversity of vaccinia virus strain Cantagalo isolated in southeastern Brazil during the early years of the outbreak, 1999-2006

Abstract: Outbreaks of a vesiculopustular disease in dairy cattle and milkers have been frequently reported in Brazil since 1999 when the vaccinia virus strain Cantagalo was first isolated in the State of Rio de Janeiro. However, the genomic diversity of the viral isolates associated with these outbreaks is not well known, particularly in the southeastern states that represent the focal point of virus spread to other regions. Here, we report the genomic sequences and an analysis of the polymorphic site profiles and geno… Show more

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Cited by 5 publications
(5 citation statements)
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“…Recently, the analysis of the complete genome of clinical isolates of the Cantagalo virus, collected in the early years and at the epicenter of the emergence of VACV in Brazil, revealed genetic characteristics not shared among the isolates. These data suggest different events of VACV spreading in the Southeastern region of Brazil, reflecting the complex genomic diversity of the isolates related to the first outbreaks [65]. The sequencing of more isolates would allow better identification of new genetic markers, elucidates the genetic diversity of BR-VACV that circulate throughout Brazil and probably in other South American countries.…”
Section: Genetic Characterization Of Brazilian Vaccinia Viruses (Br-vmentioning
confidence: 91%
“…Recently, the analysis of the complete genome of clinical isolates of the Cantagalo virus, collected in the early years and at the epicenter of the emergence of VACV in Brazil, revealed genetic characteristics not shared among the isolates. These data suggest different events of VACV spreading in the Southeastern region of Brazil, reflecting the complex genomic diversity of the isolates related to the first outbreaks [65]. The sequencing of more isolates would allow better identification of new genetic markers, elucidates the genetic diversity of BR-VACV that circulate throughout Brazil and probably in other South American countries.…”
Section: Genetic Characterization Of Brazilian Vaccinia Viruses (Br-vmentioning
confidence: 91%
“…The phylogenetic analysis based on the central conserved region of several orthopoxvirus genomes is shown in Figure 3 and reveals the regular topology of three clades in the VACV group, i.e., clade I (former American/Dryvax clade), clade II (former horsepox/Brazilian clade), and clade III (former Eurasian clade) [ 12 , 26 ]. The three clones of VACV-Wyeth were placed within the clade I, together with clones of the Dryvax vaccine ( Figure 3 ).…”
Section: Resultsmentioning
confidence: 99%
“…Despite being the first vaccine ever generated in the world, the history of the smallpox vaccine is still full of mysteries, and little is known about the evolutionary relationships of the various VACV strains used as the smallpox vaccine [ 7 , 11 , 15 , 19 , 26 ]. Here we analyzed the genetic makeup of three clones isolated from a VACV-Wyeth seed sample produced in 1971.…”
Section: Discussionmentioning
confidence: 99%
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“…DNA was recovered from cytoplasmic extracts of cells infected with each of the four clinical isolates of Goiás and used for whole genome sequencing using the Illumina platform, as described elsewhere [ 7 ]. Sequencing statistics are described in Table 1 .…”
mentioning
confidence: 99%