Genomic characterization of a novel bovine papillomavirus type 28

Yamashita‐Kawanishi, Nanako; Tsuzuki, Masano; Kasuya, Fumi; Chang, Hui‐Wen; Haga, Takeshi

doi:10.1007/s11262-020-01779-9

Cited by 12 publications

(11 citation statements)

References 24 publications

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“…Dyokappapapillomavirus with types BPV16, BPV18 and BPV22, Dyoxipapillomavirus with only BPV7, Epsilonpapillomavirus with BPV5, BPV8 and BPV25 and Xipapillomavirus with types BPV3, BPV4, BPV6, BPV9, BPV10, BPV11, BPV12, BPV15, BPV17, BPV20, BPV23, BPV24, BPV26 and BPV28. BPV19, BPV21 and BPV27 have not yet been classified [8][9][10]. The Deltapapillomavirus genus is considered to be of high risk because it contains BPV types strongly linked to the development of cancer.…”

Section: Pathogens 2020 9 X For Peer Review 2 Of 13mentioning

confidence: 99%

“…The genera are: Deltapapillomavirus , encompassing BPV1, BPV2, BPV13 and BPV14, Dyokappapapillomavirus with types BPV16, BPV18 and BPV22, Dyoxipapillomavirus with only BPV7, Epsilonpapillomavirus with BPV5, BPV8 and BPV25 and Xipapillomavirus with types BPV3, BPV4, BPV6, BPV9, BPV10, BPV11, BPV12, BPV15, BPV17, BPV20, BPV23, BPV24, BPV26 and BPV28. BPV19, BPV21 and BPV27 have not yet been classified [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil

et al. 2020

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Bovine papillomavirus (BPV) can cause damage to the epithelial and mucosal tissue and currently presents 28 known types. Not all BPV types are associated with the development of cancer in cattle. Studies have shown that variants of human papillomavirus types can present different pathogenic profiles. However, despite the similarity, it is not yet known whether variants of BPV types can also present varying degrees of pathogenicity. Thus, the aim of this study was to evaluate the genetic variability of BPV types and variants isolated in Northeastern Brazil. Samples were obtained from animals with papillomatous lesions. BPV DNA was detected by the amplification of the L1 gene and genotyping was performed by sequencing. Mutations were analyzed in a phylogenetic, structural and functional context. In total, 52 positive samples were obtained and 11 different BPV types were identified in the samples. Ten putative new BPV types were also identified. In addition, several non-synonymous mutations were identified and predicted to alter protein stability, having an impact on immune evasion. The study demonstrated a high genetic diversity of BPV in the region with a large number of mutations identified, serving as a basis for more efficient control measures to be adopted for bovine papillomatosis.

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Section: Pathogens 2020 9 X For Peer Review 2 Of 13mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil

et al. 2020

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“…Bovine papillomaviruses (BPVs) comprise 29 members grouped into five genera [ http://pave.niaid.nih.gov/ , ( 2 , 3 )]. BPV-1,−2,−13, and−14, considered to be highly pathogenic ( 4 ), belong to Deltapapillomavirus genus (δPV).…”

Section: Introductionmentioning

confidence: 99%

Association Between BoLA-DRB3.2 Polymorphism and Bovine Papillomavirus Infection for Bladder Tumor Risk in Podolica Cattle

et al. 2021

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Blood samples from 260 unrelated cattle (132 animals affected by papillomavirus-associated bladder tumors and 128 healthy) were genotyped using the classic polymerase chain reaction/restriction fragment length polymorphism method to screen MHC class II bovine leukocyte antigen-DRB3. 2 polymorphism. The DRB3*22 allele was significantly (p ≤ 0.01) detected in healthy cattle, thus appearing to have a negative association (protective effect) with virus infection of the urinary bladder known to represent a bladder tumor risk for cattle living free at pasture. Considering the two sequence alleles identified in animals carrying DRB3*22, DRB3*011:01 allele from samples of animals harboring the unexpressed bovine papillomaviruses (BPV)-2 E5 gene was characterized by amino acid residues believed to have a protective effect against BPV infection such as arginine at position 71 (R71) in pocket 4, histidine at position 11 (H11) in pocket 6, and both glutamine at position 9 (Q9) and serine at position 57 (S57) in pocket 9 of the antigen-binding groove. The DRB3*011:02v allele from affected animals was characterized by amino acids believed to be susceptibility residues such as lysine (K71), tyrosine (Y11), glutamic acid (E9), and aspartic acid (D57) in these pockets. These results suggest that animals harboring the DRB3*011:01 allele may have a lower risk of BPV infection and, consequently, a reduced risk of bladder tumors.

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“…The genome DNA of BPV is about 7800 bp, and the virus capsid is mainly composed of Ll protein [ 10 ]. So far, at least 27 genotypes of BPVs (BPV1-27) have been identified and subsequently classified into the following genera: Deltapapillomavirus genus (BPV1, BPV2, BPV13, and BPV14), Xipapillomavirus genus (BPV3, BPV4, BPV6, BPV9, BPV10, BPV11, BPV12, BPV15, BPV17, and BPV20), Epsilonpapillomavirus genus (BPV5 and BPV8), Dyokappapapillomavirus genus (BPV16, BPV18, and BPV22), Dyoxipapillomavirus (BPV7) and unclassified genera (BPV19, BPV21, and BPV27) [ 8 11 12 13 14 15 16 17 ]. Furthermore, some unclassified papillomaviruses have been subsequently reported [ 13 15 18 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, some unclassified papillomaviruses have been subsequently reported [ 13 15 18 19 ]. Recently, a novel type, designated as BPV28, from Japan was identified and characterized [ 17 ] and classified in the Xipapillomavirus genus.…”

Section: Introductionmentioning

confidence: 99%

Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

et al. 2021

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Background Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a potential threat to the dairy industry. Objectives The aim of this study is to detect and clarify the genetic diversity of BPV circulating in dairy cows in Xinjiang, China. Methods 122 papilloma skin lesions from 8 intensive dairy farms located in different regions of Xinjiang, China were detected by polymerase chain reaction. The genetic evolution relationships of various types of BPVs were analyzed by examining this phylogenetic tree. Results Ten genotypes of BPV (BPV1, BPV2, BPV3, BPV6, BPV7, BPV8, BPV10, BPV11, BPV13, and BPV14) were detected and identified in dairy cows. These were the first reported detections of BPV13 and BPV14 in Xinjiang, Mixed infections were detected, and there were geographical differences in the distribution of the BPV genotypes. Notably, the BPV infection rate among young cattle (< 1-year-old) developed from the same supply of frozen sperm was higher than that of the other young cows naturally raised under the same environmental conditions. Conclusions Genotyping based on the L1 gene of BPV showed that BPVs circulating in Xinjiang China displayed substantial genetic diversity. This study provided valuable data at the molecular epidemiology level, which is conducive to developing deep insights into the genetic diversity and pathogenic characteristics of BPVs in dairy cows.

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Genomic characterization of a novel bovine papillomavirus type 28

Cited by 12 publications

References 24 publications

High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil

High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil

Association Between BoLA-DRB3.2 Polymorphism and Bovine Papillomavirus Infection for Bladder Tumor Risk in Podolica Cattle

Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

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