Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort

Hong, Kyung‐Won; Shin, Moon Sam; Ahn, Yong-Soon; Lee, Hyun-Jin; Kim, Hyun-Duck

doi:10.1111/jcpe.12437

Cited by 50 publications

(52 citation statements)

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“…It is well established that activation of the Na-H exchanger NHE11 and increased intracellular pH (pHi) are early and universal responses to mitogens and have permissive effects in promoting cell proliferation (Putney and Barber, 2003). Our results showed a weak association between GPR141 SNP and periodontitis, and this result supports the previous result in Japanese and Korean studies (Shimizu et al, 2015;Hong et al, 2015). GPR141 is a member of the rhodopsin family of G protein-coupled receptors that include chemokine-like receptors (Fredriksson et al, 2003).…”

Section: Male (%) 43supporting

confidence: 83%

“…The genotype frequency of the current study samples were similar to previously reported Korean results (Hong et al, 2015). These results indicated that, though the sample size used in the current study is smaller, the genotype distribution was similar to the general Korean population frequency.…”

Section: Male (%) 43supporting

confidence: 80%

“…-134 -wide suggestive SNPs (1 SNP in TENM2 gene and 2 SNPs in LDLR4A gene), two non-synonymous SNPs (1 SNP in SLC9C2 gene, 1 SNP in RASGRP4 gene) and 7 replicated SNPs were reported as well as from European and Japanese studies (Hong et al, 2015). Although previously published study was the first GWAS of Korean periodontitis, there are no other independent studies that confirmed these findings.…”

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confidence: 47%

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Recapitulation of Genome-wide Association Study on Chronic Periodontitis in a Korean Population

Park

Ma²,

Park³

et al. 2017

BSL

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Periodontitis is the major causation of tooth loss in the elderly population. Multiple risk factors include oral microorganisms, smoking, metabolic syndrome, and genetic factors influence periodontitis development. In this study, we conducted a replication study of using previous Korean GWAS results by examining an independent population. The study population was recruited from Mir Dental Clinic, Daegu, Korea. In total, 93 samples were evaluated from July 2016 to January 2017. The sample groups include relatively older patients (>60 years) with no periodontitis (n = 31) and relatively younger patients (range 40~60 years) with severe periodontitis (n = 62). A total of seven markers which were previously reported to be associated with periodontitis were genotyped. Among the seven SNPs, rs16846206 and rs2392510 showed a significant association by logistic regression analysis and Chi square test, respectively. The former SNP showed significant association with severe periodontitis, whereas this study also showed same tendency in which individuals with the minor allele are significantly more frequent in cases than those in controls. The SNP is located on a coding gene (SLC9C2), where the alanine residue 505 is replaced by glycine (Ala505Gly). The later SNP was significant when differed between case and control groups, but there was no significance by logistic regression analysis when controlled for age and sex as covariant. Although the study population size examined in the current study was relatively smaller compared to previous studies, our results implicated that at least the two SNPs (rs16846206 and rs2392510) might be important candidates for the further genetic study.

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Section: Male (%) 43supporting

confidence: 83%

Section: Male (%) 43supporting

confidence: 80%

mentioning

confidence: 47%

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Recapitulation of Genome-wide Association Study on Chronic Periodontitis in a Korean Population

Park

Ma²,

Park³

et al. 2017

BSL

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“…To date, 5 genome-wide association studies (GWASs) have been conducted for CP in European American (Divaris et al 2013;Shaffer et al 2014), German (Teumer et al 2013), Japanese (Shimizu et al 2015), and Korean populations (Hong et al 2015). A variety of CP traits were examined in these GWASs, but no genome-wide significant loci have been identified for CP.…”

Section: Introductionmentioning

confidence: 99%

Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos

et al. 2016

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Chronic periodontitis (CP) has a genetic component, particularly its severe forms. Evidence from genome-wide association studies (GWASs) has highlighted several potential novel loci. Here, the authors report the first GWAS of CP among a large communitybased sample of Hispanics/Latinos. The authors interrogated a quantitative trait of CP (mean interproximal clinical attachment level determined by full-mouth periodontal examinations) among 10,935 adult participants (mean age: 45 y, range: 18 to 76 y) from the Hispanic Community Health Study / Study of Latinos. Genotyping was done with a custom Illumina Omni2.5M array, and imputation to approximately 20 million single-nucleotide polymorphisms was based on the 1000 Genomes Project phase 1 reference panel. Analyses were based on linear mixed models adjusting for sex, age, study design features, ancestry, and kinship and employed a conventional P < 5 × 10 -8 statistical significance threshold. The authors identified a genome-wide significant association signal in the 1q42.2 locus (TSNAX-DISC1 noncoding RNA, lead single-nucleotide polymorphism: rs149133391, minor allele [C] frequency = 0.01, P = 7.9 × 10 -9) and 4 more loci with suggestive evidence of association (P < 5 × 10 -6 ): 1q22 (rs13373934), 5p15.33 (rs186066047), 6p22.3 (rs10456847), and 11p15.1 (rs75715012). We tested these loci for replication in independent samples of European-American (n = 4,402) and African-American (n = 908) participants of the Atherosclerosis Risk in Communities study. There was no replication among the European Americans; however, the TSNAX-DISC1 locus replicated in the African-American sample (rs149133391, minor allele frequency = 0.02, P = 9.1 × 10 -3 ), while the 1q22 locus was directionally concordant and nominally significant (rs13373934, P = 4.0 × 10 -2 ). This discovery GWAS of interproximal clinical attachment level-a measure of lifetime periodontal tissue destruction-was conducted in a large, community-based sample of Hispanic/Latinos. It identified a genome-wide significant locus that was independently replicated in an African-American population. Identifying this genetic marker offers direction for interrogation in subsequent genomic and experimental studies of CP.

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“…A single nucleotide polymorphism (SNP) in interleukin‐1 ( IL‐1 ) was the first identified genetic risk factor for AgP . However, subsequent studies with improved statistical power using samples from homogeneous populations did not validate associations between IL‐1 variants and periodontitis . Subsequently, several genes have been identified as genetic risk factors for AgP, but the full complement of associated genes has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis

Masumoto

Kitagaki

Fujihara

et al. 2018

J of Periodontal Research

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To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case‐control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. To overcome this kind of issue, an unbiased GWAS strategy was introduced to identify genetic risk factors for various diseases. Currently, three genes glycosyltransferase 6 domain containing 1 (GLT6D1), defensin α1 and α3 (DEFA1A3), and sialic acid‐binding Ig‐like lectin 5 (SIGLEC5) that reach the threshold for genomewide significance have been identified as genetic risk factors for AgP through a case‐control GWAS.

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Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort

Abstract: Our GWAS supports a previously reported gene of TENM2 and newly suggests LDLRAD4. These two genes' role on lipid metabolism may play a part in the molecular aetiology of periodontitis.

Cited by 50 publications

References 41 publications

Recapitulation of Genome-wide Association Study on Chronic Periodontitis in a Korean Population

Recapitulation of Genome-wide Association Study on Chronic Periodontitis in a Korean Population

Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos

Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis

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