Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease

Falus, András; Fenyő, Márta; Éder, Katalin; Madarasi, Anna

doi:10.1007/s00011-011-0357-y

Cited by 3 publications

(2 citation statements)

References 16 publications

(17 reference statements)

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“…In the year of 2011, the expression of CYP4F2 was found by Falus et al to be a rapid elevation when children with respiratory disease to polarized light therapy [29]. In 2018, rs2074900 in CYP4F2 was found to be significantly related to therapeutic responses to erlotinib in sixty Han Chinese advanced non-small cell lung cancer patients received erlotinib monotherapy [16].…”

Section: Discussionmentioning

confidence: 99%

The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

Ding

Yang

et al. 2020

Respir Res

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Background: Chronic obstructive pulmonary disease (COPD) is a complex pulmonary disease. Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) belongs to cytochrome P450 superfamily of enzymes responsible for metabolism, its single nucleotide polymorphisms (SNPs) were reported to be involved in metabolism in the development of many diseases. The study aimed to assess the relation between CYP4F2 SNPs and COPD risk in the Hainan Han population. Method: We genotyped five SNPs in CYP4F2 in 313 cases and 508 controls by Agena MassARRAY assay. The association between CYP4F2 SNPs and COPD risk were assessed by χ 2 test and genetic models. Besides, logistic regression analysis was introduced into the calculation for odds ratio (OR) and 95% confidence intervals (CIs). Results: Allele model analysis indicated that rs3093203 A was significantly correlated with an increased risk of COPD. Also, rs3093193 G and rs3093110 G were associated with a reduced COPD risk. In the genetic models, we found that rs3093203 was related to an increased COPD risk, while rs3093193 and rs3093110 were related to a reduced risk of COPD. After gender stratification, rs3093203, rs3093193 and rs3093110 showed the association with COPD risk in males. With smoking stratification, rs3093144 was significantly associated with an increased risk of COPD in smokers. CYP4F2 SNPs were significantly associated with COPD risk. Conclusions: Our findings illustrated potential associations between CYP4F2 polymorphisms and COPD risk. However, large-scale and well-designed studies are needed to determine conclusively the association between the CYP4F2 SNPs and COPD risk.

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Section: Discussionmentioning

confidence: 99%

The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

Ding

Yang

et al. 2020

Respir Res

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“…However certain tissues and cellular structures, such as eye tissues, superficial skin layers, and cell monolayers, are composed of highly organized bipolar lipid layers in their cell membrane allowing a certain degree of light polarization to be transmitted [26] . Several studies report the effect of polarized light on both cells and the expression of physiologically important biomarkers [27,28,29]. The exact mechanism for the unique biological effects of polarized light remain elusive, although the superior penetration capacity of polarized compared to non-polarized light is a plausible hypothesis [30] .…”

Section: Discussionmentioning

confidence: 99%

Fluorescent light energy in wound healing: when is a photon something more?

Zago

Dehghani

Jaworska

et al. 2020

Mechanisms of Photobiomodulation Therapy XV

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Fluorescent Light Energy (FLE) is a unique form of photobiomodulation that stimulates healing, reduces inflammation, and alleviates pain. The system works by exciting a chromophore in a topical substrate, which emits FLE with a broad spectral range (~400-700 nm) that is delivered to the target tissue below. Results from in vivo and in vitro studies have shown FLE modulates inflammation via down-regulation of pro-inflammatory cytokines such as IL-6 and TNF-α, and stimulates mitochondria biogenesis 1. A recent study showed FLE-stimulated cells responded more potently compared to cells treated with light from an LED light source ("Mimicking Lamp") designed to generate the same emission spectra and power intensity profile as FLE 2. FLE-treated human dermal fibroblasts (HDF) experienced up-regulated collagen production, while a minor and nonsignificant effect was observed for the Mimicking Lamp-treated HDFs. These results suggest that photons generated by FLE either penetrate tissue differently or are absorbed differently compared to photons from a LED light source. Photonic properties of FLE that could impact tissue penetration or absorption may include polarity or coherency, leading to different cellular responses. To investigate if light polarity may influence cellular responses to FLE stimulation, the present study applied linear and circular-polarizing filters to investigate the influence of FLE's polarity on immune parameters. The data suggest that FLE polarity contributes to its impact on biological systems. Furthermore, the immunemodulatory impact of FLE was investgated in a pilot study on a human ex vivo skin model suggesting that central myeloid immune surface markes are modulated by FLE.

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Gene als Bioarchive sozialer Positionierungen? Gendertheoretische Betrachtungen neuer biologischer Embodiment-Theorien

Palm¹

2017

Verkörperungen · Embodiment

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Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease

Abstract: The improved clinical symptoms and modified gene expression profile of lymphocytes reveals an anti-inflammatory effect of whole-body polarized light irradiation.

Cited by 3 publications

References 16 publications

The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population

Fluorescent light energy in wound healing: when is a photon something more?

Gene als Bioarchive sozialer Positionierungen? Gendertheoretische Betrachtungen neuer biologischer Embodiment-Theorien

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