2007
DOI: 10.1038/nature06250
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Abstract: With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2)1. We used 'longrange haplotype' methods, which were developed to identify alleles segregating in a population that have undergone recent selection2, and we also developed new methods that are based on cross-population comparisons to discover alleles that have s… Show more

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Cited by 1,770 publications
(2,048 citation statements)
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References 34 publications
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“…The haplotypes that are more frequent and longer than expected arise because of the random processes are considered to be selected. 5 For the CR1 region, the Sardinian population group showed the strongest evidence for the difference of EP-EHH in these cross-population analyses ( Table 2). The strongest signals were for Sardinian paired with Southern Italian, Northern Italian and with the Ashkenazi groups.…”
Section: Introductionmentioning
confidence: 88%
See 1 more Smart Citation
“…The haplotypes that are more frequent and longer than expected arise because of the random processes are considered to be selected. 5 For the CR1 region, the Sardinian population group showed the strongest evidence for the difference of EP-EHH in these cross-population analyses ( Table 2). The strongest signals were for Sardinian paired with Southern Italian, Northern Italian and with the Ashkenazi groups.…”
Section: Introductionmentioning
confidence: 88%
“…These include metrics for measuring population differentiation (for example, F statistic (F st )) or unusual patterns of haplotypes (for example, integrated haplotype score, and cross-population extended haplotype homozygosity (XP-EHH)) that are suggestive of recent selection driven population sweeps. [1][2][3][4][5] Most of these studies have focused on differences between different continental groups. Although the number of studies examining differences within European populations has thus far been more limited, similar studies have identified the lactase gene as well as several genes that determine eye color.…”
Section: Introductionmentioning
confidence: 99%
“…Permutation tests were performed to estimate the genome-wide type I error rate and determine the threshold to call selective sweeps (see Supplementary Information section 2 for details) 53 . The method cross-population extended haplotype homozygosity (XP-EHH) was also tested for detecting selective sweeps using the software xpehh 54 (http://hgdp.uchicago.edu/Software/) ( Supplementary Fig. 20).…”
Section: Methodsmentioning
confidence: 99%
“…More sophisticated statistical tests build on these approaches e.g. XP-EHH (Sabeti et al, 2007, Grossman et al, 2010. These tests are often performed from in vitro cultures for drug resistance markers, with linkage mapping using laboratory crosses to correlate segregation patterns in the progeny that are associated with the drug resistant phenotype (Ferdig et al, 2004, Hayton and Su, 2008, Sanchez et al, 2011.…”
Section: Using Population Genomics To Understanding the Mode Of Pzq Rmentioning
confidence: 99%