2016
DOI: 10.1038/ncomms11664
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Hepatitis B virus (HBV) infection is a common infectious disease. Here we perform a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci involved in persistent HBV infection. GWAS scan is performed in 1,251 persistently HBV infected subjects (PIs, cases) and 1,057 spontaneously recovered subjects (SRs, controls), followed by replications in four independent populations totally consisting of 3,905 PIs and 3,356 SRs. We identify a novel locus at 8p21.3 (index rs7000921, o… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
71
1
1

Year Published

2017
2017
2021
2021

Publication Types

Select...
7
2

Relationship

2
7

Authors

Journals

citations
Cited by 54 publications
(76 citation statements)
references
References 42 publications
3
71
1
1
Order By: Relevance
“…Of them, 1,299 and 1,067 were determined as PIs and SRs, respectively10. The male/female ratio and the mean age (s.d.)…”
Section: Methodsmentioning
confidence: 99%
“…Of them, 1,299 and 1,067 were determined as PIs and SRs, respectively10. The male/female ratio and the mean age (s.d.)…”
Section: Methodsmentioning
confidence: 99%
“…A study comparing individuals who have experienced spontaneous recovery versus chronic infection identified a novel susceptibility locus for persistent HBV at chromosome 8p21.3 (87). Expression quantitative trait loci associations from liver tissues of patients with persistent infection suggested a functional role for the INTS10 gene from this region.…”
Section: Hepatitis B Virusmentioning
confidence: 99%
“…Outcomes of infections with persistent viruses, such as Human Immunodeficiency Virus (HIV), Human Hepatitis C Virus (HCV) and Human Hepatitis B virus (HBV) have been linked to the Major Histocompatibility Complex (MHC). The ability to control HIV in some ‘elite controllers’ has been linked to specific MHC Class I (MHC-I) alleles (Fellay et al, 2007; Kosmrlj et al, 2010; Kulkarni et al, 2011; Miura et al, 2009; Pereyra et al, 2010) and persistence of HCV and HBV have been linked to MHC Class II (MHC-II) alleles (Chang et al, 2014; Duggal et al, 2013; Li et al, 2016). MHC involvement in virus clearance was expected since MHC-I and MHC-II genes control CD8 + T cell responses and CD4 + T cell-dependent antibody (Ab) responses, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…Similarly, as spontaneous HCV clearance correlates with the early appearance of virus-neutralizing antibodies (Abs) (Osburn et al, 2014; Pestka et al, 2007) several MHC-II alleles of HLA-DQ were considered as candidates mediating efficient, CD4 + T cell-dependent humoral responses to this virus (Duggal et al, 2013). Further, the production of neutralizing Abs that play a key role in the recovery from infection with HBV (Ciupe et al, 2014; Huang et al, 2006) were also linked to specific HLA-DQ alleles (Chang et al, 2014; Li et al, 2016). …”
Section: Introductionmentioning
confidence: 99%