Genome-wide association study identifies 30 loci associated with bipolar disorder

Abstract

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Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals

“…28 These conform to the well-known calcium dysregulation hypothesis of bipolar disorder 55 and also the mitochondrial dysfunction hypothesis. 57,58 Because fatty acid composition of CL in the brain is unique in particular, 59 further detailed F I G U R E 8 CRC of mitochondria obtained from the brains of cKO and control mice. Large-scale, genome-wide association studies of the disease, however, highlighted FADS1,2 genes involved in the polyunsaturated fatty acids metabolism.…”

Genome‐wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications

“…We further filtered to extract SNP with genome‐wide significance (5 × 10 −8 ) and detected 39 variants as candidate SNP. In addition, we searched bioRxiv (http://www.biorxiv.org/) manually and found the latest results reported by Stahl et al That study identified 30 SNP with genome‐wide significance associated with BD.…”

“…Among the 27 studies (Table ), 12 studies (69 SNP) showed genome‐wide significance (Table ). Ten of the 12 studies comprising a European‐based sample were analyzed, and two studies targeted East Asian/European subjects in the discovery phases (Table ).…”

“…Recently, the largest study led by the PGC was posted on bioRxiv (http://www.biorxiv.org/content/early/2017/08/08/173062.1). The sample size was striking and comprised approximately 30 000 BD cases (20 352 discovery GWAS and 9412 replicates) and ~169 000 controls (31 358 discovery GWAS and 137 760 replicates). In this study, they reported 30 loci as susceptibility genes for BD, and 20 loci were novel; the most significant association was observed at the SNP in TRANK1 (rs9834970, P = 5.7 × 10 −12 , OR = 0.93), which had been reported previously (Table ).…”

“…In a recent report by Stahl et al the authors analyzed the relationship among BD subtypes (BD I, II, and SA) and SCZ/MDD. Interestingly, they observed that: (i) the polygenic score based on SCZ risk was higher in BD I than in BD II; whereas (ii) scores based on MDD risk were higher in BD II than in BD I.…”