2021
DOI: 10.3390/ani11082424
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Abstract: Livestock is an important commodity playing a major role in the global economy. Red meat plays an important role in human life, as it is a good source of animal protein and energy. The fatty acid content of beef has been shown to impact the eating experience and nutritional value of beef. Therefore, this study aimed to identify genomic regions which can account for genetic variation in meat fatty acid content. Genotypes imputed to the Illumina BovineHD 770K BeadChip were used in this study. Thirty-six 1-Mb gen… Show more

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Cited by 6 publications
(6 citation statements)
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“…FASN is a multifunctional enzyme that catalyzes the synthesis of fatty acids by catalyzing NADPH (reductase II) and malonyl. Studies have reported that upregulation of the FASN gene increases the UFA content, whereas its downregulation increased the content of octadecanoic acid in muscles, resulting in higher SFA in the Pingliang Red Cattle and Simmental cattle compared to the Wagyu cross F1 generation. DEGs and DAMs were significantly enriched in the regulation of lipolysis in adipocytes between Pingliang Red Cattle and Simmental cattle, and arachidonic acid enriched in this pathway positively regulated PUFA, causing higher PUFA levels in Pingliang Red Cattle than Simmental cattle.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…FASN is a multifunctional enzyme that catalyzes the synthesis of fatty acids by catalyzing NADPH (reductase II) and malonyl. Studies have reported that upregulation of the FASN gene increases the UFA content, whereas its downregulation increased the content of octadecanoic acid in muscles, resulting in higher SFA in the Pingliang Red Cattle and Simmental cattle compared to the Wagyu cross F1 generation. DEGs and DAMs were significantly enriched in the regulation of lipolysis in adipocytes between Pingliang Red Cattle and Simmental cattle, and arachidonic acid enriched in this pathway positively regulated PUFA, causing higher PUFA levels in Pingliang Red Cattle than Simmental cattle.…”
Section: Discussionmentioning
confidence: 99%
“…The ACACA gene, a marker for affecting IMF, is associated with synthesizing long-chain fatty acids . The high expression of SCD is known to convert SFAs into MUFAs in adipocytes, resulting in higher UFAs and lower SFAs in Wagyu cross F1 generation . Correlation analysis revealed that the expression of these genes was significantly and positively correlated with marbling, unsaturated fatty acid content, and muscle tenderness, indicating these genes to be involved in regulating fat deposition and muscle tenderness in the Pingliang Red Cattle and Wagyu cross F1 generation.…”
Section: Discussionmentioning
confidence: 99%
“…The enzyme FASN catalyses the de novo synthesis of palmitic acid, a substrate for palmitoleic acid synthesis through desaturation, and stearic acid through elongation [92][93][94]. Genome-wide association studies with varying breeds of cattle have reported significant effect of FASN SNP on intramuscular composition of SFA, MUFA, and linoleic acid [91,[95][96][97][98]. Previous studies had reported that FASN polymorphism significantly influenced the intramuscular composition of oleic acid, SFA and MUFA in Fleckvieh bulls [41], and palmitic acid, palmitoleic acid, oleic acid, SFA, and MUFA of the intramuscular adipose tissue in Japanese Black cattle [36,82,99].…”
Section: Fatty Acid Synthase Gene Polymorphismsmentioning
confidence: 99%
“…Several studies have been published on candidate genes related to fatty acid composition, mainly in pigs and cattle [9][10][11][12]. The major candidate genes related to fatty acids are FASN, SCD, FABP2, and ELOVL7.…”
Section: Introductionmentioning
confidence: 99%