2021
DOI: 10.1186/s13059-021-02398-9
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Abstract: Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from geno… Show more

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Cited by 95 publications
(83 citation statements)
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“…The conserved gene in humans is a replicated GWAS hit for the intrinsic rate of epigenetic aging. [26][27][28] In the BXDs, Stxbp4 contains several non-coding variants, and a missense mutation (rs3668623), and the expression of Stxbp4 in liver is modulated by a cis-eQTL. Stxbp4 plays a key role in insulin signaling, 38 and has oncogenic activity and implicated in different cancers.…”
Section: Discussionmentioning
confidence: 99%
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“…The conserved gene in humans is a replicated GWAS hit for the intrinsic rate of epigenetic aging. [26][27][28] In the BXDs, Stxbp4 contains several non-coding variants, and a missense mutation (rs3668623), and the expression of Stxbp4 in liver is modulated by a cis-eQTL. Stxbp4 plays a key role in insulin signaling, 38 and has oncogenic activity and implicated in different cancers.…”
Section: Discussionmentioning
confidence: 99%
“…We do not delve into these in the present work, but the Chr3 interval is near genes associated with human epigenetic aging (Ift80, Trim59, Kpna4). 26,28 However, this QTL is dispersed across a large interval, and the peak markers do not exactly overlap these human EAA GWAS hits. While we have focused on Eaaq11 and Eaaq19, these other loci also present potentially important regions for EAA.…”
Section: Discussionmentioning
confidence: 99%
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