2016
DOI: 10.1186/s12864-016-2511-y
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Abstract: BackgroundSaturated fatty acids can be detrimental to human health and have received considerable attention in recent years. Several studies using taurine breeds showed the existence of genetic variability and thus the possibility of genetic improvement of the fatty acid profile in beef. This study identified the regions of the genome associated with saturated, mono- and polyunsaturated fatty acids, and n-6 to n-3 ratios in the Longissimus thoracis of Nellore finished in feedlot, using the single-step method.R… Show more

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Cited by 66 publications
(66 citation statements)
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References 88 publications
(104 reference statements)
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“…The authors reported some regions near to DEG identified in this study. In this regard, the ACSM3 and ACSM1 genes were differentially expressed for ω3 acids and were located in a region (BTA25, 12 Mb) which explained more than 1 % of the additive variance genetic for ω3, as reported by [52]. Those authors also reported QTL detected by GWAS in the same region that the TNXB (tenascin XB) and PPARD (peroxisome proliferator-activated receptor delta) genes were differentially expressed in this study.…”
Section: Discussionsupporting
confidence: 82%
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“…The authors reported some regions near to DEG identified in this study. In this regard, the ACSM3 and ACSM1 genes were differentially expressed for ω3 acids and were located in a region (BTA25, 12 Mb) which explained more than 1 % of the additive variance genetic for ω3, as reported by [52]. Those authors also reported QTL detected by GWAS in the same region that the TNXB (tenascin XB) and PPARD (peroxisome proliferator-activated receptor delta) genes were differentially expressed in this study.…”
Section: Discussionsupporting
confidence: 82%
“…In a recent GWAS study, [52] used a population with 963 Nellore bulls, which contained 48 animals used in this study, and identified several genomic regions which explained more than 1 % of the additive genetic variance for beef FAs composition. The authors reported some regions near to DEG identified in this study.…”
Section: Discussionmentioning
confidence: 99%
“…Previous genome-wide association studies have been conducted for fatty acid composition in multiple cattle breeds, including Angus, Japanese Black, Nellore and other crossbreds [8, 30, 32, 35, 36]. To our knowledge, this study is the first attempt to investigate molecular mechanism underling fatty acid composition using high density SNP array and evaluate the accuracy of genomic predictions in Chinese Simmental cattle population.…”
Section: Discussionmentioning
confidence: 99%
“…Despite the fact that single-SNP based GWAS methods have been widely used in many studies, these methods may not be powerful for studying the complex traits with low or moderate heritability. Due to the polygenic characteristics of fatty acid composition in cattle, GWAS using the Bayesian methods have enabled to identify many associated loci that have missed by the single-SNP regression approach [33, 35, 36]. BayesB has been widely used for GWAS of complex trait in farm animals [3942].…”
Section: Discussionmentioning
confidence: 99%
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