2018
DOI: 10.1038/s41467-018-04951-w
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Abstract: Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of which (39 common and 3 rare variants) are independent of the known variants. Integration of the gene expression data from blood (n = 14,115 and 2765) with the GWAS results identifies 33 putative functional genes for … Show more

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Cited by 585 publications
(417 citation statements)
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“…We estimated of height, BMI and T2D to be 0.38 ± h g 2 0.08, 0.25 ± 0.06 and 0.26 ± 0.08 respectively. These results were similar to reported values from UK Biobank 32 and other studies 10,33 for European populations. Although estimands differed in different studies ( Methods ), we noted that without covLDSC, we would have obtained severely deflated estimates ( Table 1 ).…”
Section: Application To Sigma and 23andme Cohortssupporting
confidence: 92%
See 1 more Smart Citation
“…We estimated of height, BMI and T2D to be 0.38 ± h g 2 0.08, 0.25 ± 0.06 and 0.26 ± 0.08 respectively. These results were similar to reported values from UK Biobank 32 and other studies 10,33 for European populations. Although estimands differed in different studies ( Methods ), we noted that without covLDSC, we would have obtained severely deflated estimates ( Table 1 ).…”
Section: Application To Sigma and 23andme Cohortssupporting
confidence: 92%
“…Reported values are estimates of (with standard deviations in h g 2 brackets) from LDSC using a 20cM window, covLDSC using a 20cM window and 10 PCs, and GCTA using REAP to obtain the genetic relationship matrix with adjustment by 10 PCs. The final column provides reported estimates in European populations from various studies 10,32,33 .…”
Section: Appendix Insample Versus Outofsample Ldmentioning
confidence: 99%
“…We also note overlap between our identified LOY associated loci and other complex traits and diseases. For example, seven of our current LOY signals are correlated with previously reported 44 susceptibility loci for Type 2 diabetes (TP53INP1, SUGP1, KCNQ1, CCND2, EIF2S2, PTH1R and BCL2L11). At six of these overlapping loci, the LOY risk-increasing allele also increases the risk of Type 2 diabetes.…”
Section: Discussionsupporting
confidence: 79%
“…This SNP is intergenic to 369 CTRB1-2 and BCAR1 (Figure 5). While BCAR1 is ubiquitous, CTRB1-2 is expressed 370 exclusively in the exocrine pancreas and genetic variation therein has been previously 371 associated with alcoholic pancreatitis 28 and type-2 diabetes 29,30 . The expression of both 372 genes is reduced in tumors vs. normal tissue 31 .…”
Section: Biological Annotation Of Lmi-regions Variants Prioritized Amentioning
confidence: 99%