Genome-wide Approaches Reveal Functional Vascular Endothelial Growth Factor (VEGF)-inducible Nuclear Factor of Activated T Cells (NFAT) c1 Binding to Angiogenesis-related Genes in the Endothelium

C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling

“…Previous reports have shown that VEGF upregulates Adamts-1 mRNA (12,31) and that NFATc1 binds the Adamts-1 promoter upon VEGF treatment in ECs (32). Nevertheless, a detailed analysis of the transcriptional mechanisms involved in Adamts-1 induction by VEGF had not been performed.…”

Wnt5a/Ca 2+ /calcineurin/nuclear factor of activated T signaling pathway as a potential marker of pediatric melanoma

“…This phenomenon leads to NFAT nuclear translocation and binding to the specific DNA binding site, [62] thereby regulating the transcription and expression of downstream target genes, such as COX-2 and vascular endothelial growth factor-A (VEGF-A), which may influence tumor development. [63,64] Clone formation and cell transformation in fibroblasts are induced by activated NFAT2; calcineurin and NFAT2 may induce Myc transcription to enhance the proliferation and nonadherence-dependent growth of pancreatic cancer cells.…”

Development of a robust reporter-based assay for the bioactivity determination of anti-VEGF therapeutic antibodies

“…Calcineurin signaling activates nuclear factor of activated T cells (NFAT), a transcription factor that directs a number of multifunctional downstream targets in endothelial cells. VEGF-mediated calcineurin-NFAT signaling axis is one of the key angiogenesis regulatory pathways [31].…”

“…VEGFR2, also known as kinase insert domain receptor (KDR), is widely considered to be the main receptor responsible for angiogenesis [23][24][25][26][27][28]. KDR has been shown to activate several signaling pathways, including PKC/ Ca2+-calcineurin, PI3K, and MAPK [29][30][31]. Calcineurin signaling activates nuclear factor of activated T cells (NFAT), a transcription factor that directs a number of multifunctional downstream targets in endothelial cells.…”