Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels

French, Anne; Ogden, Rob; Eland, Cathlene; Hemani, Gibran; Pong‐Wong, Ricardo; Corcoran, Brendan; Summers, Kim M.

doi:10.1016/j.tvjl.2011.09.011

Cited by 27 publications

(68 citation statements)

References 16 publications

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“…Congestive heart failure is observed in many breeds (Isono et al 2012), as are cardiomyopathy (Mausberg et al 2011, Meurs et al 2012, Owczarek-Lipska et al 2013b), ventricular arrhythmia ( Jesty et al 2013), and mitral valve disease (Fox 2012, French et al 2012). For some disorders, such as dilated cardiomyopathy in the Irish Wolfhound, many loci are involved (Philipp et al 2012).…”

Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 99%

Insights into Morphology and Disease from the Dog Genome Project

Schoenebeck

Ostrander

2014

Annu. Rev. Cell Dev. Biol.

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Although most modern dog breeds are less than 200 years old, the symbiosis between man and dog is ancient. Since prehistoric times, repeated selection events have transformed the wolf into man’s guardians, laborers, athletes, and companions. The rapid transformation from pack predator to loyal companion is a feat that is arguably unique among domesticated animals. How this transformation came to pass remained a biological mystery until recently: Within the past decade, the deployment of genomic approaches to study population structure, detect signatures of selection, and identify genetic variants that underlie canine phenotypes is ushering into focus novel biological mechanisms that make dogs remarkable. Ironically, the very practices responsible for breed formation also spurned morbidity; today, many diseases are correlated with breed identity. In this review, we discuss man’s best friend in the context of a genetic model to understand paradigms of heritable phenotypes, both desirable and disadvantageous.

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Section: Genetics Of Canine Diseases Inform Human Conditionsmentioning

confidence: 99%

Insights into Morphology and Disease from the Dog Genome Project

Schoenebeck

Ostrander

2014

Annu. Rev. Cell Dev. Biol.

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“…These publications underlie the role genetics play in this acquired disease (Lewis et al 2011). French et al (2012) have shown that the disease is not a result of a single gene effect in the CKCS, emphasizing the necessity to find specific mutations when making decisions related to breeding dogs. Stern et al (2015) have shown that disease severity may also be associated with genetic factors in Whippets.…”

Section: Introductionmentioning

confidence: 99%

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Garncarz¹,

Hulanicka²,

Maciejewski³

et al. 2016

Polish Journal of Veterinary Sciences

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Studies identifying specific pathologically expressed genes have been performed on diseased myocardial tissue samples, however less invasive studies on gene expression of peripheral blood mononucleated cells give promising results. This study assessed transcriptomic data that may be used to evaluate Dachshunds with chronic mitral valve disease. Dachshunds with different stages of heart disease were compared to a control, healthy group. Microarray data analysis revealed clusters of patients with similar expression profiles. The clusters were compared to the clinical classification scheme. Unsupervised classification of the studied groups showed three clusters. Clinical and laboratory parameters of patients from the cluster 1 were in accordance with those found in patients without heart disease. Data obtained from patients from the cluster 3 were typical of advanced heart failure patients. Comparison of the cluster 1 and 3 groups revealed 1133 differentially expressed probes, 7 significantly regulated process pathways and 2 significantly regulated Ariadne Metabolic Pathways. This study may serve as a guideline for directing future research on gene expression in chronic mitral valve disease.

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“…[1] This condition is known as myxomatous valve degeneration (mvd), a heart disease commonly acquired by small dog breeds during adulthood. [2] The disease does not have a defined etiology, and for this reason several hypotheses have arisen about the ways in which genetics and hemodynamic and endogenous factors may affect the disease.…”

Section: Introductionmentioning

confidence: 99%

“…[13,14] The aim of this review is to further understand the latest developments of myxomatous degeneration in order to prevent these complications. 1 This article is the result of a research project of the National Comittee for Research Development (Conadi according to its initials in Spanish) at Universidad Cooperativa de Colombia.…”

Section: Introductionmentioning

confidence: 99%

Myxomatous valve degeneration

et al. 2013

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Abstract. This review article is an analysis of the most recent published scientific articles about myxomatous valve degeneration (mvd) and was conducted over a five month period. The aim of this review is to consolidate information about the most recent medical developments in regards to myxomatous degeneration in the mitral valve. The authors of this article reached a consensus on both the development of the disease and the most effective type of diagnosis and treatment that is available today. Myxomatous valve degeneration is the most common heart disease in the canine population. It is identified by a loss of mechanical integrity in the heart due to structural changes in the valvular components. Degenerative changes occur due to an accumulation of mucopolysaccharides in the leaflets and chordae which affect the proper operation of the valve apparatus. This is caused by faulty coaptation of the leaflets, resulting in mitral or tricuspid regurgitation, dilated ventricles and annuli, which are lesions that eventually cause the rupture of the chordae tendineae, leading to complications or possibly death. Due to the gradual progression of the disease and the presence or absence of clinical signs, it is very important that veterinarians accurately diagnose and follow-up on these patients in order to achieve stabilization and provide a suitable prognosis and treatment plan. The current ideal treatment of the disease is a low-sodium diet, administration of the ace inhibitor (angiotensin-converting-enzyme inhibitor) spironolactone and a diuretic in order to reduce the presence of pulmonary edema and avoid the progression of the disease to congestive heart failure.Keywords: av valves, canine, heart, Myxomatous degeneration, treatment. Degeneração valvar mixomatosa. Um olhar nos últimos avanços em todos os aspectos da doençaResumo. Este artigo de revisão se realizou durante um período de cinco meses. Incluíram-se, neste, os últimos avanços publicados em artigos científicos. Conseguiu-se realizar um consenso quanto ao desenvolvimento da doença, ao tipo de diagnóstico mais adequado e ao tratamento que melhores resultados está mostrando na atualidade. O objetivo desta revisão foi conhecer as últimas atualizações sobre a degeneração valvular mixomatosa. A degeneração valvar mixomatosa é a doença cardíaca mais comum na população canina, na qual há uma perda da integridade mecânica devido a mudanças estruturais nos componentes valvulares. As mudanças se devem a uma acumulação de mucopolisacáridos nas cordas tendíneas e nas valvas as quais iniciam com falhas na coaptação das valvas gerando uma regurgitação mitral ou tricuspidiana, dilatação dos ventrículos e do anel valvular, levando a complicações ou morte do paciente. Devido ao progresso gradual das lesões na doença e à manifestação ou não de signos clínicos, o diagnóstico exato e seguimento apropriado desses pacientes é de grande importância para os médicos veterinários com o objetivo de prognosticar e instaurar o tratamento adequado. O melhor tratamento na atualidade para...

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Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels

Cited by 27 publications

References 16 publications

Insights into Morphology and Disease from the Dog Genome Project

Insights into Morphology and Disease from the Dog Genome Project

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Myxomatous valve degeneration

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