Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Carlton, Jane M.; Angiuoli, Samuel V.; Suh, Bernard; Kooij, Taco W. A.; Pertea, Mihaela; Silva, Joana C.; Ermolaeva, Maria D.; Allen, Jonathan; Selengut, Jeremy D.; Koo, Hean; Peterson, Jeremy; Pop, Mihai; Kosack, Daniel S.; Shumway, Martin; Bidwell, Shelby L.; Shallom, Shamira; Aken, Susan E. Van; Riedmuller, Steven B.; Feldblyum, Tamara; Cho, Jennifer K.; Quackenbush, John; Sedegah, Martha; Shoaibi, Azadeh; Cummings, Leda M.; Florens, Laurence; Yates, John R.; Raine, J. Dale; Sinden, Robert E.; Harris, Michael A.; Cunningham, Deirdre; Preiser, Peter R.; Bergman, Lawrence W.; Vaidya, Akhil B.; Lin, Leo H. van; Janse, Chris J.; Waters, Andrew P.; Smith, Hamilton O.; White, Owen; Salzberg, Steven L.; Venter, J. Craig; Fraser, Claire M.; Hoffman, Stephen L.; Gardner, Malcolm J.; Carucci, Daniel J.

doi:10.1038/nature01099

Cited by 668 publications

(501 citation statements)

References 59 publications

(52 reference statements)

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“…P. yoelii was chosen since it is the only other parasite whose genome sequence has been published [19]. Once again, tRNAs were chosen as an internal control to determine the e value for the BLAST analysis and to serve as a check for program efficiency.…”

Section: A Bioinformatics Strategy Identifies Candidate Ncrnas From Tmentioning

confidence: 99%

A screen for conserved sequences with biased base composition identifies noncoding RNAs in the A–T rich genome of Plasmodium falciparum

Upadhyay

Bawankar

Malhotra

et al. 2005

Molecular and Biochemical Parasitology

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Section: A Bioinformatics Strategy Identifies Candidate Ncrnas From Tmentioning

confidence: 99%

A screen for conserved sequences with biased base composition identifies noncoding RNAs in the A–T rich genome of Plasmodium falciparum

Upadhyay

Bawankar

Malhotra

et al. 2005

Molecular and Biochemical Parasitology

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“…This limits the perception of the complex development in erythrocytes and ham pers the recognition and study of dynamic processes in these stages. This gap in malaria biology contrasts with the detailed knowledge of the parasite's genome, transcriptome and proteome [30][31][32][33] .…”

mentioning

confidence: 97%

Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions

et al. 2011

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Blood stages of Plasmodium falciparum cause the pathology of malaria; however, the progression of the parasite through this complex part of the life cycle has never been visualized. In this study, we use four-dimensional imaging to show for the first time the development of individual parasites in erythrocytes and the concomitant host cell modifications. our data visualize an unexpectedly dynamic parasite, provide a reference for this life cycle stage and challenge the model that protein export in P. falciparum is linked to the biogenesis of host cell modifications termed maurer's clefts. our results provide a novel view of the blood-stage development, maurer's cleft development and protein export in malaria parasites, and open the door to study dynamic processes, drug effects and the phenotype of mutants.

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“…The genome projects [1,2] in conjunction with RNA subtraction studies [29] have led to the identification of many more microneme and rhoptry proteins of sporozoites. Two of these, TRAP (thrombospondin-related anonymous protein; [64]) and AMA-1 (apical membrane antigen 1; [65]), have been characterized in some detail and several lines of evidence support a role for these proteins in hepatocyte invasion.…”

Section: Sporozoite and Hepatocyte Proteins Involved In The Invasion mentioning

confidence: 99%

“…Until recently, our knowledge of the molecular interactions between host and parasite during this stage of infection was limited due to the small number of sporozoites and EEFs present in the mammalian host and to the lack of an in vitro system for growing sporozoites. With the sequencing of the human and rodent malaria parasite genomes [1,2] as well as advances in transfection [3][4][5] and intravital microscopy [6], our knowledge of these stages has increased dramatically. Here we summarize what is currently known about the interaction between Plasmodium sporozoites and their mammalian host, beginning with sporozoite injection into the dermis and ending with invasion of their target, the hepatocyte.…”

Section: Introductionmentioning

confidence: 99%

A long and winding road: The Plasmodium sporozoite's journey in the mammalian host

Sinnis

Coppi

2007

Parasitology International

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Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Cited by 668 publications

References 59 publications

A screen for conserved sequences with biased base composition identifies noncoding RNAs in the A–T rich genome of Plasmodium falciparum

A screen for conserved sequences with biased base composition identifies noncoding RNAs in the A–T rich genome of Plasmodium falciparum

Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions

A long and winding road: The Plasmodium sporozoite's journey in the mammalian host

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