Genome-free Viral Capsids as Carriers for Positron Emission Tomography Radiolabels

Hooker, Jacob M.; O’Neil, James P.; Romanini, Dante W.; Taylor, Scott; Francis, Matthew B.

doi:10.1007/s11307-008-0136-5

Cited by 54 publications

(51 citation statements)

References 37 publications

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“…MS2 particles have been labeled with [ 18 F]-fluorobenzaldehyde and evaluated in rats. These experiments showed that although [ 18 F]fluorobenzaldehyde is rapidly cleared from the circulation, [ 18 F]-MS2 particles can persist for at least 3 hours (Figure 3) [76**]. In a different study, iron oxide nanoparticles and 18 F-fluoride were encapsulated into envelopes derived from Hemagglutinating virus of Japan (HVJ), and achieved a similarly high signal-to-noise imaging resolution in PET.…”

Section: From Engineering To Potential Applications In Medicinementioning

confidence: 99%

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Applications of viral nanoparticles in medicine

Yildiz

Shukla

Steinmetz

2011

Current Opinion in Biotechnology

264

234

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Several nanoparticle platforms are currently being developed for applications in medicine, including both synthetic materials and naturally-occurring bionanomaterials such as viral nanoparticles (VNPs) and their genome-free counterparts, virus-like particles (VLPs). A broad range of genetic and chemical engineering methods have been established that allow VNP/VLP formulations to carry large payloads of imaging reagents or drugs. Furthermore, targeted VNPs and VLPs can be generated by including peptide ligands on the particle surface. In this article, we highlight state-of-the-art virus engineering principles and discuss recent advances that bring potential biomedical applications a step closer. Viral nanotechnology has now come of age and it will not be long before these formulations assume a prominent role in the clinic.

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Section: From Engineering To Potential Applications In Medicinementioning

confidence: 99%

“…In contrast, [ 18 F]-MS2 remained in circulation for the duration of the experiment (3 hours) as seen in the figure. Reproduced with permission from reference [76]. …”

Section: Figurementioning

confidence: 99%

Applications of viral nanoparticles in medicine

Yildiz

Shukla

Steinmetz

2011

Current Opinion in Biotechnology

264

234

View full text Add to dashboard Cite

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“…A popular click chemistry strategy used with VNPs is copper-catalyzed azide-alkyne cycloaddition (CuAAC) between azides and alkynes in the presence of Cu(I), irreversibly yielding the biocompatible 1,4-substituted triazole derivative (19, 28, 33–37). In addition, azo-coupling can be used to introduce payloads into VNPs (32, 38–40). Typically, an aldehyde is first introduced onto the VNP surface by azo-coupling to a bifunctional linker.…”

Section: Modification Strategies: From Scaffolds To Functional Entitiesmentioning

confidence: 99%

Virus-Based Nanoparticles as Versatile Nanomachines

et al. 2015

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Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases. Viruses have played a special role in these developments because they can function as prefabricated nanoscaffolds that have unique properties and are easily modified. The interiors of virus particles can encapsulate and protect sensitive compounds, while the exteriors can be altered to display large and small molecules in precisely defined arrays. These properties of viruses, along with their innate biocompatibility, have led to their development as actively targeted drug delivery systems that expand on and improve current pharmaceutical options. Viruses are naturally immunogenic, and antigens displayed on their surface have been used to create vaccines against pathogens and to break self-tolerance to initiate an immune response to dysfunctional proteins. Densely and specifically aligned imaging agents on viruses have allowed for high-resolution and noninvasive visualization tools to detect and treat diseases earlier than previously possible. These and future applications of viruses have created an exciting new field within the disciplines of both nanotechnology and medicine.

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“…The first studies on the generation of nanoparticles for magnetic resonance imaging applications and the first comparisons of interior versus exterior cargo strategies appeared in the mid 2000s [271,272]. Following these reports, MS2 VLPs were loaded with positron emission tomography radiolabels [273]. To date, MS2 phages and VLPs have played a leading role in bioimaging studies.…”

Section: Nonvaccine Applicationsmentioning

confidence: 99%

The True Story and Advantages of RNA Phage Capsids as Nanotools

et al. 2016

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RNA phages are often used as prototypes for modern recombinant virus-like particle (VLP) technologies. Icosahedral RNA phage VLPs can be formed from coat proteins (CPs) and are efficiently produced in bacteria and yeast. Both genetic fusion and chemical coupling have been successfully used for the production of numerous chimeras based on RNA phage VLPs. In this review, we describe advances in RNA phage VLP technology along with the history of the Leviviridae family, including its taxonomical organization, genomic structure, and important role in the development of molecular biology. Comparative 3D structures of different RNA phage VLPs are used to explain the level of VLP tolerance to foreign elements displayed on VLP surfaces. We also summarize data that demonstrate the ability of CPs to tolerate different organic (peptides, oligonucleotides, and carbohydrates) and inorganic (metal ions) compounds either chemically coupled or noncovalently added to the outer and/or inner surfaces of VLPs. Finally, we present lists of nanotechnological RNA phage VLP applications, such as experimental vaccines constructed by genetic fusion and chemical coupling methodologies, nanocontainers for targeted drug delivery, and bioimaging tools.

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Genome-free Viral Capsids as Carriers for Positron Emission Tomography Radiolabels

Abstract: These studies provide further insight into the pharmacokinetic behavior of nanomaterials and serve as a platform for the future development of targeted imaging and therapeutic agents based on mtMS2.

Cited by 54 publications

References 37 publications

Applications of viral nanoparticles in medicine

Applications of viral nanoparticles in medicine

Virus-Based Nanoparticles as Versatile Nanomachines

The True Story and Advantages of RNA Phage Capsids as Nanotools

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