2015
DOI: 10.1074/jbc.m114.617324
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Background: There are seven histone H1 variants in somatic mammalian cells, two of which are replication-independent, H1.0 and H1X. Results: In breast cancer cells, H1.0 is enriched at nucleolus-associated domains, whereas H1X is associated with RNA polymerase II-enriched regions. Conclusion: Most H1 variants show great redundancy across the genome, but there is also some specificity. Significance: Some H1 variants may have specific functions.Unlike core histones, the linker histone H1 family is more evolution… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

5
68
0
1

Year Published

2016
2016
2019
2019

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 58 publications
(74 citation statements)
references
References 79 publications
5
68
0
1
Order By: Relevance
“…Consistent with a previous report (27), we also found that the binding preference was different between H1.0 and H1.X. Both the GDs and CTDs contribute to determining the binding site ( Fig.…”
Section: Discussionsupporting
confidence: 82%
See 2 more Smart Citations
“…Consistent with a previous report (27), we also found that the binding preference was different between H1.0 and H1.X. Both the GDs and CTDs contribute to determining the binding site ( Fig.…”
Section: Discussionsupporting
confidence: 82%
“…In particular, it was recently reported that the mobility of H1.X in the nucleus was much higher than that of other linker histone variants (26). In addition, the binding preferences of H1.0 and H1.X to the 5S rRNA genes, telomeric satellites, and actively transcribed genes were reported to be different (27). Although distinct stability and preferences of chromatin binding of individual linker histones should contribute to the organization of high-order chromatin structures and to the regulation of gene expression, the regulatory mechanism by which the chromatin binding stability and the binding site preferences of linker histones are determined is currently not understood.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…An early instructive example of transcriptional repression by H1 in Xenopus laevis shows that reduced H1 expression leads to the upregulation of 5S rRNA expression (69). More recent studies have suggested gene-specific transcriptional regulation by H1 as opposed to global effects and that H1 subtypes have an uneven distribution across the genome (70,71). For example, chromatin immunoprecipitation (ChIP) showed a relative depletion of human H1.2 and H1.4 in actively transcribed chromatin, whereas all somatic subtypes were detected in heterochromatin (72).…”
Section: Figmentioning
confidence: 99%
“…H3K27me3 methyl-transferase EZH2 is upregulated in a number of cancers, including breast cancer, lymphomeans of stimulating gene silencing through chromatin compaction via EZH2-mediated H3K27 trimethylation, as well as establishing the essentiality of the C-terminal tail of H1.2 in its binding to chromatin for transcription inactivation, research has buttressed the role of histone H1.2 in gene regulation; functioning as a linker that builds chromatin compactions as well as silencing genes via the identification of H3K27me3 [24]. Core histones which include H2A, H2B, H3 and H4 along with linker histones H1 and H5, play very important roles in compacting DNA strands and also in regulating transcription [22]. [19].…”
Section: Histonesmentioning
confidence: 99%