Genital warts and other HPV infections: Established and novel therapies

Fathi, Ramin; Tsoukas, Maria M.

doi:10.1016/j.clindermatol.2013.08.014

Cited by 54 publications

(58 citation statements)

References 52 publications

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“…Condyloma acuminata (genital warts) are sexually transmitted benign neoplasms that may involve the vulva, vagina, cervix, urethra, anal canal, and perianal skin. Recurrent anogenital warts is a frequent cause of medical vulvitis with a reported 360,000 occurrences [ 39 ]. However, in recent years, the appearance of a quadrivalent (HPV genotypes 6, 11, 16, and 18) or bivalent (HPV types 6 and 11) vaccine is changing the epidemiologic landscape of genital warts.…”

Section: Human Papillomavirus Infection (Condyloma Cuminata: Genital mentioning

confidence: 99%

“…6.12a, b ). Affects 1 % of sexually active adults with the highest incidence in the second and third decade [ 39 ]. The incubation period can range from 3 weeks to 8 months with a clinically apparent lesion within 2-3 months after infection [ 41 ].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…HPV is responsible for benign and malignant processes that affect the vulva, including condyloma acuminata and squamous cell carcinomas. Genital human papillomavirus is a common sexually transmitted infection (STI) with a transmission rate of approximately 65 % [ 39 ]. There are more than 40 types of HPV that can infect the genital areas of males and females, and they can infect the mouth and throat as well.…”

Section: Human Papillomavirus Infection (Condyloma Cuminata: Genital mentioning

confidence: 99%

See 2 more Smart Citations

Infectious Diseases and Infestations of the Vulva

Selim

Parra²,

Sangüeza

et al. 2014

Vulvar Pathology

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Section: Human Papillomavirus Infection (Condyloma Cuminata: Genital mentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Section: Human Papillomavirus Infection (Condyloma Cuminata: Genital mentioning

confidence: 99%

See 1 more Smart Citation

Infectious Diseases and Infestations of the Vulva

Selim

Parra²,

Sangüeza

et al. 2014

Vulvar Pathology

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“…Infection with 'high-risk' HPV is associated with the development of precancerous lesions [8]. Treatments on genital warts are mainly divided into medications and surgery, medications include imiquimod, podophyllin, podofilox and trichloroacetic acid, surgery include freezing with liquid nitrogen, electrocautery, surgical excision and laser treatments [9,10]. Although the short-time effect of above treatment is good, the transmission rate of the related HPV infection is as high as 65%, with a high risk of recurrence [7].…”

mentioning

confidence: 99%

Distribution of Human Papillomavirus Genotypes (2014–2016) in Women With Genital Warts at a Sexually Transmitted Disease Clinic in Beijing, China

Jiang

et al. 2018

Future Virol.

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Aim:The aim of this study was to analyze the distribution of human papillomavirus (HPV) genotypes among women with genital warts in the Beijing region of China. Methods: A total of 350 women diagnosed with genital warts between 2014 and 2016 were analyzed by real-time polymerase chain reaction (PCR) to test for high-risk and low-risk HPV subtypes. Results: The results show that 52.6% (184/350) of cases were positive for HPV6+11. The three most common high-risk HPVs detected were HPV52, HPV16 and HPV58, detected in 12.0% (42/350), 10.6% (37/350) and 10.0% (35/350) of all cases, respectively. Conclusion: These results indicate that vaccines targeting HPV subtypes 6, 11, 16, 52 and 58 would have the greatest impact among sexually active women living in Beijing. Human papillomaviruses (HPVs) are small double-stranded DNA viruses that belong to the family of papillomavirus [1]. There are as many as 170 HPV genotypes have been identified [2], and approximately 40 kinds of these types specially infect the anogenital tract [3]. Genital warts are evident skin or mucosal growths in the anogenital area display as flat, papular or pedunculated growths on the genital mucosa [4]. Genital warts are one of the most common sexually transmitted diseases with a high prevalence (0.5%) in Asia [5,6]. The disease results from infection with 'low-risk' HPV subtypes [7]. Infection with 'high-risk' HPV is associated with the development of precancerous lesions [8]. Treatments on genital warts are mainly divided into medications and surgery, medications include imiquimod, podophyllin, podofilox and trichloroacetic acid, surgery include freezing with liquid nitrogen, electrocautery, surgical excision and laser treatments [9,10]. Although the short-time effect of above treatment is good, the transmission rate of the related HPV infection is as high as 65%, with a high risk of recurrence [7]. Thus, effective prevention against HPV transmission and infection is essential. Accordingly, many countries have implemented HPV vaccination programs.A recent study by Chang et al. [11] indicates that the distribution of HPV subtypes differs among various regions throughout China. Comparison of other studies reporting on HPV prevalence in China indicates wide geographic variability in subtype distribution [12], thus undermining the selection of the most effective vaccine. Up to date, several vaccines have been developed to prevent HPV infection. Gardisil is a quadrivalent vaccine containing four genotypes, namely 16, 18, 6 and 11; and Cervarix (GSK) is a bivalent vaccine containing 16 and 18. In addition to providing excellent protection against the HPV types contained in the vaccine, Gardisil has also demonstrated significant cross-protection to other oncogenic types in both naive and previously infected women [13].In order to identify the distribution of HPV subtypes in the Beijing area, samples collected from women with genital warts treated at a sexually transmitted disease clinic were examined. The results will contribute to the data

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“…With the use of HPV vaccines, the incidence of the warts has been decreased. [198] If these warts remain untreated, they can either regresses spontaneously or they can grow larger and become more numerous resulting in complicated cases. [192] Therefore, prevention HPV infection and therefore formation of these warts will be the optimum goal.…”

Section: Role Of Hpv In Non-cancerous Diseasesmentioning

confidence: 99%

The role of human papillomaviruses in cancer progression

Tulay¹,

Serakıncı²

2016

JCMT

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The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken. In the last decade, development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers. In this report, we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

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Genital warts and other HPV infections: Established and novel therapies

Cited by 54 publications

References 52 publications

Infectious Diseases and Infestations of the Vulva

Infectious Diseases and Infestations of the Vulva

Distribution of Human Papillomavirus Genotypes (2014–2016) in Women With Genital Warts at a Sexually Transmitted Disease Clinic in Beijing, China

The role of human papillomaviruses in cancer progression

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