Genital Paget's Disease

Carcinoma in situ of the Skin: A Review of Histopathology

“…Extramammary Paget's disease is an entity whose origin is unresolved (Becker et al 1960, Murrell & McMuIlan 1962. Its histologic appearance includes individual cells and nests of atypical clear cells in the epidermis.…”

Extramammary paget's disease. A case report.

“…Pathologically, the main problem is to differentiate extramammary Paget's disease from malignant melanoma, Bowen's dis ease, and occasionally from erythroplasia of Queyrat. This is especially true for the malignant melanoma (2,6,11,13).…”

“…Like mammary glands, the apocrine glands are under influence of hormones. They begin functioning at puberty, with In disagreement with this vicw these cells are able to spread rapidly in tissue culture ( 2). Clinically the disease is described as erythematous and scaling, with secondary weeping, oozing and eczematisation.…”

Dopa Oxidase and P 32 Uptake in Extramammary Paget's Disease of the Vulva

“…Thus, the preferential up take of P 32 hy t he extram am m ary Paget's disease of the vulva might be very helpful when used to determine the spread of the disease and may facilitate to outline the extent of surgical intervention. The presence of melanin in the cytoplasm of the Paget's cells has been investigated by several authors [2,3,4,17,19] and by us [18]. The interpretation of this finding is rather difficult and will need much more investigation.…”