Abstract:0003). A lower CD4؉ count nadir was strongly associated with genital dysplasia (P ؍ .0003).Conclusion: A history of greater immunosuppression, as measured by the nadir of a patient's CD4
“…In addition, infiltrating lymphocytes are correlated with regression of genital warts in both humans and animal models (28 -31). In the setting of HIV infection, peripheral CD4 counts are inversely correlated with the presence of CIN, indicating a protective role of CD4ϩ T cells in this population (32). Because our study is a cross-sectional study, the functional role of the lymphocytic infiltrates in CIN lesions cannot be ascertained.…”
“…In addition, infiltrating lymphocytes are correlated with regression of genital warts in both humans and animal models (28 -31). In the setting of HIV infection, peripheral CD4 counts are inversely correlated with the presence of CIN, indicating a protective role of CD4ϩ T cells in this population (32). Because our study is a cross-sectional study, the functional role of the lymphocytic infiltrates in CIN lesions cannot be ascertained.…”
“…26 Although HIV viral load in our study was not predictive of CIN, the association of CIN with higher HIV viral load warrants further investigation.…”
“…Th e prevalence of cervical dysplasia was 3.9-fold higher among HIV-infected women than among women not infected with HIV (Duerr et al 2001). Before highly active antiretroviral therapy (HAART) became the standard of care for patients infected with HIV, the risk of cervical dysplasia increased progressively as immune function declined; as measured by the fall in CD4 ϩ cells (Taylor et al 2004).…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.