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“…In young OVX rats, for example, bone loss was prevented by genistein, a selective estrogen receptor modulator (SERM) analog. 54 Genistein has been shown to increase osteoblast differentiation via the nitric oxide/cyclic guanosine monophosphate pathway and BMC in the tibia and femur of young mice 55 and the vertebral body of L4 vertebra in middle-aged OVX rats. 56 In OVX mice, daidzen and calcium, when given together, protect bone and increase bone strength in the lumbar vertebrae, femur diaphysis, and femur neck.…”
Section: Family Fabaceaementioning
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“…In young OVX rats, for example, bone loss was prevented by genistein, a selective estrogen receptor modulator (SERM) analog. 54 Genistein has been shown to increase osteoblast differentiation via the nitric oxide/cyclic guanosine monophosphate pathway and BMC in the tibia and femur of young mice 55 and the vertebral body of L4 vertebra in middle-aged OVX rats. 56 In OVX mice, daidzen and calcium, when given together, protect bone and increase bone strength in the lumbar vertebrae, femur diaphysis, and femur neck.…”
Section: Family Fabaceaementioning
“…In most isoflavones and deoxybenzoins, the alkylation of the hydroxy groups was very selective; the hydroxy group at the R 1 position was more active. [12] Thus, for compounds 20, 23, 26, 29, and 32, only one of two free phenolic hydroxy groups in the starting deoxybenzoin were alkylated in good yields.…”
Section: Resultsmentioning
“…[20][21][22] These differences may be due to variation in genistin or genistein forms. Wang et al 24 showed that different derivatives of genistein had different bone-sparing effects due to ovareictomy. They showed that ash weight of bone and BMD of Ovx rats receiving sulfonated genistein were pronouncedly higher than Ovx rats.…”
Section: Discussionmentioning