Genetics of Tumors of the Head and Neck

Pediatric Head and Neck Malignancies

“…Retinoblastoma, which was the first form of cancer directly linked to a gene, is caused by a deletion or mutation of the q14 band of chromosome 13. 16 After performing an analysis identical to that performed in the other cohorts, we found that the incidence of retinoblastoma had remained static from the 1973-1975 rate of 0.36 (95% CI, 0.26-0.46) to the 1994-1996 rate of 0.36 (95% CI, 0.27-0.45) despite significant rate increases at other head and neck sites (Table 4).…”

Osteosarcoma of the head and neck: A review of the johns hopkins experience

“…Many different predisposing factors to OS have been identified, including retinoblastoma, Li‐Fraumeni syndrome, and prior radiation exposure. It has been hypothesized that both a mutation of the RB1 gene and the TP53 gene are needed to impart susceptibility to osteosarcoma 21 . Two of 27 patients in this series were treated for retinoblastoma and eventually were diagnosed with OS approximately 101 and 111 months later, respectively.…”

Burkitt’s Lymphoma in the Base of the Tongue: Differential Diagnosis and Management

“…Immunohistochemistry shows CD10-positive cells corresponding to relatively immature B cells. Chromosome investigation shows that in most cases there is a translocation from chromosome 8 to the immunoglobulin heavy-chain region on chromosome 14 or one of the light-chain loci on chromosome 2 or 22 [4,9]. These translocations are usually near or concern the c-myc oncogene.…”