Genetics of Retinoblastoma

Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862-1995

“…Earlier reports1 5 11 36 failed to show clustering of sporadic hereditary or non-hereditary retinoblastoma in specific months. Our data revealed fluctuations to some extent by month of birth, but this was not statistically significant.…”

Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862-1995

“…Earlier reports1 5 11 36 failed to show clustering of sporadic hereditary or non-hereditary retinoblastoma in specific months. Our data revealed fluctuations to some extent by month of birth, but this was not statistically significant.…”

The Genetics of Retinoblastoma, Revisited

“…Although it has often been stated that there are no sex differences in the incidence of retinoblastoma (Falls and Neel 1951; Leelawongs and Regan 1968;Francois et al 1975;Suckling et al 1982), a cursory examination of the literature reveals many more studies reporting an excess of male cases than studies indicating an excess of female cases. This trend has been noted by previous investigators (Jensen 1965;Francois et al 1975), but we know of no large, systematic compilation of reports that divide cases according to sex, laterality, and family history.…”

“…We have analyzed 189 retinoblastoma pedigrees (Griffith and Sorsby 1944;Falls and Neel 1951;Macklin 1959; Barry and Mullaney 1971;Czeizel and Gardonyi 1974;Matsunaga and Ogyu 1976;Khodadoust et al 1977; Francois et al 1978;Connolly et al 1983;Cavenee et al 1985Cavenee et al , 1986Costanzi et al 1989;Scheffer et al 1989;Yandell and Dryja 1989;Goddard et al 1990;Greger et al 1990;Holladay et al 1991;Weir-Thompson et al 1991;Lohmann et al 1992;Munier et al 1992;Onadim et al 1992aOnadim et al , 1992b; B. L. Gallie, unpublished data; F. Munier, unpublished data; E. Costanzi, unpublished data; M. Wang, unpublished data; M. F. Hansen and L. Strong, unpublished data) for segregation of the trait according to sex of transmitting parent and sex of all offspring. These results are shown in table 2.…”

Occurrence of Mental Retardation in Patients With Retinoblastoma

“…I n a case reported by Orye et al (1971), the patient with bilateral retinoblastoma and a deletion of the long arm of a D chromosome had bilateral clinodactyly and cleft uvula but no mental retardation. However, in the wide array of malformations reported in D-deletion syndrome, mental retardation frequently has been found (Jensen & Miller 1971) and there have been two cases of D-deletion syndrome with retinoblastoma and mental retardation (Francois et al 1972). Hence mental retardation with retinoblastoma may represent a variant of this chromosomal disorder (Miller & Jensen 1971).…”

Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862-1995

“…Earlier reports1 5 11 36 failed to show clustering of sporadic hereditary or non-hereditary retinoblastoma in specific months. Our data revealed fluctuations to some extent by month of birth, but this was not statistically significant.…”

The Genetics of Retinoblastoma, Revisited

“…Although it has often been stated that there are no sex differences in the incidence of retinoblastoma (Falls and Neel 1951; Leelawongs and Regan 1968;Francois et al 1975;Suckling et al 1982), a cursory examination of the literature reveals many more studies reporting an excess of male cases than studies indicating an excess of female cases. This trend has been noted by previous investigators (Jensen 1965;Francois et al 1975), but we know of no large, systematic compilation of reports that divide cases according to sex, laterality, and family history.…”

“…We have analyzed 189 retinoblastoma pedigrees (Griffith and Sorsby 1944;Falls and Neel 1951;Macklin 1959; Barry and Mullaney 1971;Czeizel and Gardonyi 1974;Matsunaga and Ogyu 1976;Khodadoust et al 1977; Francois et al 1978;Connolly et al 1983;Cavenee et al 1985Cavenee et al , 1986Costanzi et al 1989;Scheffer et al 1989;Yandell and Dryja 1989;Goddard et al 1990;Greger et al 1990;Holladay et al 1991;Weir-Thompson et al 1991;Lohmann et al 1992;Munier et al 1992;Onadim et al 1992aOnadim et al , 1992b; B. L. Gallie, unpublished data; F. Munier, unpublished data; E. Costanzi, unpublished data; M. Wang, unpublished data; M. F. Hansen and L. Strong, unpublished data) for segregation of the trait according to sex of transmitting parent and sex of all offspring. These results are shown in table 2.…”

Occurrence of Mental Retardation in Patients With Retinoblastoma

“…I n a case reported by Orye et al (1971), the patient with bilateral retinoblastoma and a deletion of the long arm of a D chromosome had bilateral clinodactyly and cleft uvula but no mental retardation. However, in the wide array of malformations reported in D-deletion syndrome, mental retardation frequently has been found (Jensen & Miller 1971) and there have been two cases of D-deletion syndrome with retinoblastoma and mental retardation (Francois et al 1972). Hence mental retardation with retinoblastoma may represent a variant of this chromosomal disorder (Miller & Jensen 1971).…”

Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862-1995

“…Earlier reports1 5 11 36 failed to show clustering of sporadic hereditary or non-hereditary retinoblastoma in specific months. Our data revealed fluctuations to some extent by month of birth, but this was not statistically significant.…”

The Genetics of Retinoblastoma, Revisited

“…Although it has often been stated that there are no sex differences in the incidence of retinoblastoma (Falls and Neel 1951; Leelawongs and Regan 1968;Francois et al 1975;Suckling et al 1982), a cursory examination of the literature reveals many more studies reporting an excess of male cases than studies indicating an excess of female cases. This trend has been noted by previous investigators (Jensen 1965;Francois et al 1975), but we know of no large, systematic compilation of reports that divide cases according to sex, laterality, and family history.…”

“…We have analyzed 189 retinoblastoma pedigrees (Griffith and Sorsby 1944;Falls and Neel 1951;Macklin 1959; Barry and Mullaney 1971;Czeizel and Gardonyi 1974;Matsunaga and Ogyu 1976;Khodadoust et al 1977; Francois et al 1978;Connolly et al 1983;Cavenee et al 1985Cavenee et al , 1986Costanzi et al 1989;Scheffer et al 1989;Yandell and Dryja 1989;Goddard et al 1990;Greger et al 1990;Holladay et al 1991;Weir-Thompson et al 1991;Lohmann et al 1992;Munier et al 1992;Onadim et al 1992aOnadim et al , 1992b; B. L. Gallie, unpublished data; F. Munier, unpublished data; E. Costanzi, unpublished data; M. Wang, unpublished data; M. F. Hansen and L. Strong, unpublished data) for segregation of the trait according to sex of transmitting parent and sex of all offspring. These results are shown in table 2.…”

Occurrence of Mental Retardation in Patients With Retinoblastoma

“…I n a case reported by Orye et al (1971), the patient with bilateral retinoblastoma and a deletion of the long arm of a D chromosome had bilateral clinodactyly and cleft uvula but no mental retardation. However, in the wide array of malformations reported in D-deletion syndrome, mental retardation frequently has been found (Jensen & Miller 1971) and there have been two cases of D-deletion syndrome with retinoblastoma and mental retardation (Francois et al 1972). Hence mental retardation with retinoblastoma may represent a variant of this chromosomal disorder (Miller & Jensen 1971).…”