Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa

Konopelski, Piotr; Konop, Marek; Perlejewski, Karol; Bukowska-Osko, Iwona; Radkowski, Marek; Onyszkiewicz, Maksymilian; Jaworska, Kinga; Mogilnicka, Izabella; Samborowska, Emilia; Ufnal, Marcin

doi:10.1097/hjh.0000000000002864

Cited by 8 publications

(25 citation statements)

References 45 publications

(68 reference statements)

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“…Intercaecal administration of investigated compounds and the collection of samples requires surgical preparation [39,40] and potential use of antibiotics that might significantly affect microbial data. Due to this fact, the colon is more frequently used for the evaluation of microbial communities and their impact on health in mammals [41,42]. The gut lumen is separated from the circulation by layers of tissues, which altogether form the gut-blood barrier (GBB).…”

Section: Gut-blood Barrier (Gbb) and Microbiotamentioning

confidence: 99%

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

Konopelski

Mogilnicka

2022

IJMS

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Actions of symbiotic gut microbiota are in dynamic balance with the host’s organism to maintain homeostasis. Many different factors have an impact on this relationship, including bacterial metabolites. Several substrates for their synthesis have been established, including tryptophan, an exogenous amino acid. Many biological processes are influenced by the action of tryptophan and its endogenous metabolites, serotonin, and melatonin. Recent research findings also provide evidence that gut bacteria-derived metabolites of tryptophan share the biological effects of their precursor. Thus, this review aims to investigate the biological actions of indole-3-propionic acid (IPA), a gut microbiota-derived metabolite of tryptophan. We searched PUBMED and Google Scholar databases to identify pre-clinical and clinical studies evaluating the impact of IPA on the health and pathophysiology of the immune, nervous, gastrointestinal and cardiovascular system in mammals. IPA exhibits a similar impact on the energetic balance and cardiovascular system to its precursor, tryptophan. Additionally, IPA has a positive impact on a cellular level, by preventing oxidative stress injury, lipoperoxidation and inhibiting synthesis of proinflammatory cytokines. Its synthesis can be diminished in the presence of different risk factors of atherosclerosis. On the other hand, protective factors, such as the introduction of a Mediterranean diet, tend to increase its plasma concentration. IPA seems to be a promising new target, linking gut health with the cardiovascular system.

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Section: Gut-blood Barrier (Gbb) and Microbiotamentioning

confidence: 99%

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

Konopelski

Mogilnicka

2022

IJMS

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“…Gut microbiota-derived molecules may affect cardiovascular homeostasis acting directly on the blood vessels and the heart (31,32). Reciprocally, changes in the cardiovascular system may affect gut microbiota by altering the structure and function of bacterial habitat, i.e., intestines (33). It has been found that gut bacteria may affect the circulatory system indirectly by modulating gut sympathetic activity (34) and RAS.…”

Section: Ras and Gut Microbiota In Health And Disease Cardiovascular Systemmentioning

confidence: 99%

Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels

Jaworska

Koper

Ufnal

2021

American Journal of Physiology-Gastrointestinal and Liver Physi

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Gut microbiota is a potent biological modulator of many physiological and pathological states. The renin-angiotensin system (RAS), including the local gastrointestinal RAS (GI RAS), emerges as a potential mediator of microbiota-related effects. The RAS is involved in cardiovascular system homeostasis, water-electrolyte balance, intestinal absorption, glycemic control, inflammation, carcinogenesis and aging-related processes. Ample evidence suggests a bidirectional interaction between the microbiome and RAS. On the one hand, gut bacteria and their metabolites may modulate GI and systemic RAS. On the other hand, changes in the intestinal habitat caused by alterations in RAS may shape microbiota metabolic activity and composition. Notably, the pharmacodynamic effects of the RAS-targeted therapies may be in part mediated by the intestinal RAS and changes in the microbiome. This review summarizes studies on gut microbiota and RAS physiology. Expanding the research on this topic may lay a foundation for new therapeutic paradigms in gastrointestinal diseases and multiple systemic disorders.

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“…It is important to note that the complexity of the microbiota can produce unexpected results such as increased BP in Dahl salt‐sensitive rats receiving fecal transplants from salt‐resistant normotensive rats 9 . A recent study on inter‐strain fecal transplant in rats showed no effect on BP and did not produce long‐term changes in gut bacteria composition 130 …”

Section: Treatment Of Hypertension Based On Gut Microbesmentioning

confidence: 99%

“…9 A recent study on inter-strain fecal transplant in rats showed no effect on BP and did not produce long-term changes in gut bacteria composition. 130…”

Section: Fmtmentioning

confidence: 99%

Regulatory effect of gut microbes on blood pressure

Yan

Sun

Zhou

et al. 2022

Anim Models and Exp Med

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Hypertension is an important global public health issue because of its high morbidity as well as the increased risk of other diseases. Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans. In this review, we outline the interaction between gut microbiota and hypertension, including gut microbial changes in hypertension, the effect of microbial dysbiosis on blood pressure (BP), indicators of gut microbial dysbiosis in hypertension, and the microbial genera that affect BP at the taxonomic level. For example, increases in Lactobacillus, Roseburia, Coprococcus, Akkermansia, and Bifidobacterium are associated with reduced BP, while increases in Streptococcus, Blautia, and Prevotella are associated with elevated BP. Furthermore, we describe the potential mechanisms involved in the regulation between gut microbiota and hypertension. Finally, we summarize the commonly used treatments of hypertension that are based on gut microbes, including fecal microbiota transfer, probiotics and prebiotics, antibiotics, and dietary supplements. This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut microbiota in hypertension.

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Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 45 publications

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels

Regulatory effect of gut microbes on blood pressure

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