Genetic variation (population database) at 20 autosomal STR loci in the population of Rajasthan (north-western India)

Kumar, Anand; Kumar, Rajesh; Kumawat, R. K.; Tilawat, Ajay Kumar; Shrivastava, Pankaj; Chaubey, Gyaneshwer

doi:10.1007/s00414-020-02280-6

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…One of the double-copy locus, DYS385a/b has shown three or four alleles during genotyping (23) . The two samples used in the present study showed that sample 1 has six alleles (12,13,14,17,18,21) whereas sample 2 has five alleles (13,18,19,20,21)…”

Section: Resultsmentioning

confidence: 60%

“…United Kingdom develop their population data by NDNAD (National DNA Database) (10) whereas Europe has its own DNA database-ENFSI(The European Network of Forensic Science Institutes) (11) . Several states in India also have their population data based on the forensic casework (12),( 13),( 14), ( 15), ( 16), (17). DYF399S1, DYF387S1, DYS526a, DYF403S1a, DYF404S1Y-STRs are known for their high mutation rate (18) .…”

Section: Introductionmentioning

confidence: 99%

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Rare Finding of a Triallelic Pattern at The DYF387S1 Locus in the Population of Rajasthan, India

Anand Kumar,

Rajesh Kumar,

Ginni Kumawat

et al. 2022

MLU

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This study reported a sexual assault case where Y-STR DNA profile was tested for the confirmation of male DNA. Within the DNA profile of the sample of accused, a tri-allelic pattern was detected at locus DYF387S1. Since this locus doesn't exist in any of the commercially available Y-STR amplification kits, So, the confirmation of this tri-allelic pattern was done by re-extracting and amplifying the extracted DNA by using Y-Filer Plus amplification kit (Thermo Fischer Scientific, CA, USA-Thermo) followed by separation of amplicons on Genetic Analyzer 3500xl.The allelic patterns of case sample belong to Type-2 pattern of tri-allelic outcome because peak heights were in balanced manner. This region is very much prone towards any structural mutation which could be either addition or deletion of allele, so for the forensic point of view this locus should be used carefully for kinship analysis.

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Section: Resultsmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Rare Finding of a Triallelic Pattern at The DYF387S1 Locus in the Population of Rajasthan, India

Anand Kumar,

Rajesh Kumar,

Ginni Kumawat

et al. 2022

MLU

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“…As observed, both the forensic parameters have higher values and thus indicates greater degree of genomic diversity in the Gujarat population. (Ghosh et al, 2011;Imam et al, 2018;Mohapatra et al, 2019;Kumar et al, 2020;Kumawat et al, 2020) . Paired genetic distance (RST) and their corresponding values were estimated at the same 17 Y-STRs by comparing the haplotypes of studied population and other thirteen published populations haplotypes using Analysis of Molecular Variance (AMOVA) (Table 2).…”

Section: Haplotypes Analysismentioning

confidence: 99%

Estimating the Genetic Polymorphisms of Gujarat Population using 17 Y Chromosomal STR loci

Mishra¹,

Gondhali²,

Choudhary³

2021

OnLine Journal of Biological Sciences

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“…This case report marks a breakthrough in the observation of microsatellite mutation in the studied population. Genetic diversity including autosomal and Y-STRs on the population of Rajasthan is well established by some authors [2], [3], [4]. Indian sequencing datasets are underreported globally although India has 17% of the world population having extensive genetic diversity so it is very important to report any microsatellite mutations in the Indian scenario.…”

Section: Introductionmentioning

confidence: 99%

Maternal allele mutation: Slippage synthesis furnishing evolutionary trend

Kumar¹,

Kumar²,

Kumawat³

et al. 2021

GSC Biol. and Pharm. Sci.

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Gain or loss of repeat motifs leads to an allelic mismatch in the disputed child which is a deviation from the Mendelian inheritance, thereby leading to a paternal mismatch of putative father or exclusion of mother in case of maternal allelic mismatch. This allelic mismatch at one or more loci is a major cause of forensic inferences. The biological samples of the case were genotyped using Powerplex®- Fusion 5C system kit and Investigator® Argus X-12 QS kit as per recommendations of the manufacturer. In this case, identification of a putrefied dead body with 22 autosomal STR loci, primarily analyzed by Powerplex®- Fusion 5C system kit divulged a maternal mismatch at locus D13S317. Alleles at the locus D13S317 allegedly belonging to the father of the deceased and the mother were observed as 10/11, 11/11 and 10/10 respectively. To rule out allelic mismatch at this particular locus, 12 X-STR loci were amplified, in which all the maternal alleles of deceased completely matched with the mother. This case study indicates the extension of one microsatellite repeat motif (TATC) at locus D13S317 in the population of Rajasthan. The reported mutation rate was 0.14% and 0.04% at locus D13S317 in paternal and maternal meiosis respectively.

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Genetic variation (population database) at 20 autosomal STR loci in the population of Rajasthan (north-western India)

Cited by 6 publications

References 15 publications

Rare Finding of a Triallelic Pattern at The DYF387S1 Locus in the Population of Rajasthan, India

Rare Finding of a Triallelic Pattern at The DYF387S1 Locus in the Population of Rajasthan, India

Estimating the Genetic Polymorphisms of Gujarat Population using 17 Y Chromosomal STR loci

Maternal allele mutation: Slippage synthesis furnishing evolutionary trend

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