Genetic variation in IL-10 influences the progression of hepatitis B infection

Abstract

The outcomes of hepatitis B virus (HBV) infection vary substantially among affected individuals, providing evidence of the role of host genetic background in the susceptibility to HBV persistence and the dynamics of liver injury progression to cirrhosis and hepatocellular carcinoma (HCC). Methods: Six single-nucleotide polymorphisms within the interleukin 10 gene (IL10) were genotyped by MALDI-TOF mass spectrometry in 857 patients with chronic HBV infection (CHB), 48 patients with resolved HBV infection, and 100 healthy volunteers. Associations of the selected polymorphisms with susceptibility to chronic HBV infection, liver injury progression, and outcomes were investigated. Results: IL10 À819T (rs1800871), À592A (rs1800872), and +504T (rs3024490) alleles were associated with treatment-induced hepatitis B surface antigen (HBsAg) seroclearance. Additionally, IL10 ATAC haplotype increased the chance of HBsAg loss and was significantly more frequent in patients with less liver injury. Moreover rs1800871TT, rs1518110TT, rs1800872AA, and rs3024490TT genotypes were identified as predictors of a lower FIB-4 score (<0.5). Conclusions: This study indicates that polymorphisms within the promoter region and intronic sequences of IL10 are associated with chronicity of hepatitis B and with HBV-induced liver damage.

Sex‐differences in the association of interleukin‐10 and interleukin‐12 variants with the progression of hepatitis B virus infection in Caucasians

“…29 Furthermore, the ATAC haplotype was reported to be associated with treatment-induced HBsAg and less severe liver injury. 30 This is in contrast to the present study, where the IL-10 rs1800896 AG/GG genotypes are associated with spontaneous HBsAg SC and with the development of IC in female white European patients. Female patients carrying the favorable variants had almost twofold higher chances to spontaneously clear the virus or to convert to inactive carriers, respectively.…”

Genetic polymorphisms in TLR3, IL10 and CD209 influence the risk of BK polyomavirus infection after kidney transplantation

“…IL-10 is a key regulatory component of the immune response that suppresses T-cell proliferation, antigen-presenting cell functions and production of pro-inflammatory cytokines during the recovery stage following infection, in order to limit the inflammation-mediated tissue damage 34 . Previous studies have reported the effect of IL10 polymorphisms on the susceptibility to human immunodeficiency virus infection 35 , 36 or the risk of HBV-induced liver damage and progression to chronicity 37 . A large proportion of the interindividual variability observed in the production of human IL-10 is attributable to genetic variation in the highly polymorphic promoter region of the IL10 gene, where the rs1800872 SNP is located 38 .…”

Functional Cure of Hepatitis B Virus Infection in Individuals With HIV-Coinfection: A Literature Review

“…Several studies have found that genetic variants on the human leucocyte antigen (HLA)-DP gene are associated with HBsAg-seroclearance during the natural history of infection [ 64 ] or during treatment with NA [ 65 ], which seems to be consistent across different populations [ 66 ]. Other polymorphisms on genes linked to immunological function, such as the toll-like receptor 3 [ 67 ], interleukin 10 [ 68 ], and T-cell immunoglobulin and mucin domain-containing molecule 3 genes [ 69 ], have also shown to be linked to the natural progression of HBV infection and are less consistently studied [ 66 ]. There have been very few studies examining the role of genetic polymorphisms on HBsAg-seroclearance in HIV-HBV co-infected individuals, apart from the IL28B haplotype showing no association [ 70 ].…”