Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population

Fonseca, Ana Carolina Proença da; Marchesini, Bruna; Zembrzuski, Verônica Marques; Voigt, D; Ramos, Vivianne Galante; Carneiro, João Régis Ivar; Neto, José Firmino Nogueira; Cabello, Giselda M. K.; Cabello, Pedro Hernán

doi:10.1590/1678-4685-gmb-2018-0264

Cited by 10 publications

(10 citation statements)

References 32 publications

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“…Many studies have detected an association between the first intron of FTO SNPs and obesity in various ethnicities and populations (Baturin et al, 2014; da Fonseca et al, 2020; Hubacek et al, 2008; Hubacek et al, 2009; Luczynski et al, 2012). While some studies support our results of non‐significant associations, Haupt et al (2008) and Li et al (2008) record that inconsistencies exist, and Bravard et al (2013) more recently considered that FTO variant association with BMI largely depended on the population examined and then suggested that the effects of FTO variants might interact with environmental factors such as nutrition and lifestyle‐dependent energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

“…The fat mass and obesity‐associated gene ( FTO ; ID 79068, OMIM accession number 610966) is composed of nine exons which span over 400 kb on chromosome 16 (Deng et al, 2018; Frayling et al, 2007; Huang et al, 2011). Polymorphisms in the FTO first intron are significantly associated with increased risk of adverse metabolic traits, including type 2 diabetes (Hubacek et al, 2018) hypertension (Pausova et al, 2009) metabolic syndrome (Freathy et al, 2008; Sedaghati‐khayat et al, 2018) and triglyceride levels (da Fonseca et al, 2020). A number of studies have demonstrated close correlation between FTO variants rs9939609, rs1421085, and rs7817449, which are almost in complete linkage, and the occurrence of obesity and body mass index (BMI) in both children and adults (Ahmad et al, 2010; Cho et al, 2020; Dina et al, 2007; Ehrlich & Friedenberg, 2016; He et al, 2014; Khan et al, 2018; Liu et al, 2013; Manco et al, 2019; Scuteri et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Falbová

Vorobeľová

Siváková

et al. 2021

American J Hum Biol

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Objectives: This cross-sectional study investigates associations between the FTO rs 17817449 genetic variant, liver enzymes, and hypertension in Slovak midlife women. Methods: We assessed 576 Slovak women aged 39 to 65 years. The women were interviewed and examined during their medical examination at local Health Centers and then divided into subgroups according to their blood pressure status; 255 women with hypertension and 321 normotensive. The FTO genetic variant was detected by polymerase chain reaction-restriction fragment length polymorphism. Resultant data was analyzed by linear regression analysis and general linear models to adjust for risk factors associated with gammaglutamyl transferase levels (GGT), including waist to hip ratio (WHR) and uric acid (UA). Results: A significant association between the FTO variant and GGT levels was observed in the hypertensive group after control for confounding covariates, including WHR and UA (p = .004). The predicted GGT level for GT/TT hypertensive carriers is 0.158 μkat/L higher than for GG carriers. Moreover, the two-way analysis of covariance revealed significant interaction between FTO effects and hypertension on logGGT levels (p = .042). Finally, hypertensive women with the T-allele had the highest estimated marginal mean value of logGGT at À0.39 μkat/L while the GG-genotype in both hypertensive and normotensive women had the lowest value at À0.54 μkat/L.Conclusions: This study suggests that the FTO (rs17817449) variant is associated with higher serum GGT levels in hypertensive midlife women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Falbová

Vorobeľová

Siváková

et al. 2021

American J Hum Biol

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“…FTO gene has been suggested to control energy homeostasis and food intake (Abete et al 2020). Previous studies have shown that, of the various obesity susceptibility genes, single-nucleotide polymorphisms (SNPs) located in the first intron of FTO gene has provided the strongest evidence for genetic predisposition to obesity (Frayling et al 2007;Scuteri et al 2007;Speliotes et al 2010;Loos and Yeo 2014;Babenko et al 2019;Fonseca et al 2020). The minor allele 'A' of the FTO SNP rs9939609 has been consistently associated with higher BMI in various populations (Frayling et al 2007;Hertel et al 2011;Peng et al 2011;Corella et al 2012;Li et al 2012;Qi et al 2014;Wang et al, 2020;Schlauch et al 2020).…”

Section: Introductionmentioning

confidence: 99%

FTO gene–lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population

Isgin-Atici

Alsulami

Turan-Demirci

et al. 2020

International Journal of Food Sciences and Nutrition

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FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish populationThe aim of the study was to investigate whether lifestyle factors modify the association fat mass and obesity-associated (FTO) gene single nucleotide polymorphisms (SNPs) and obesity in a Turkish population. The study included 400 unrelated individuals, aged 24-50 years recruited in a hospital setting. Dietary intake and physical activity were assessed using 24-hour dietary recall and self-report questionnaire, respectively. A genetic risk score (GRS) was developed using FTO SNPs, rs9939609 and rs10163409. Body mass index and fat mass index were significantly associated with FTO SNP rs9939609 (P=0.001 and P=0.002, respectively) and GRS (P=0.002 and P=0.003, respectively). The interactions between SNP rs9939609 and physical activity on adiponectin concentrations, and SNP rs10163409 and dietary protein intake on increased waist circumference were statistically significant (Pinteraction=0.027 and Pinteraction=0.044, respectively). This study demonstrated that the association between FTO SNPs and central obesity might be modified by lifestyle factors in this Turkish population.

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Section: Introductionmentioning

confidence: 99%

“…The FTO polymorphism is suggested to be the strongest genetic determinant of common obesity [7], also predisposing to extreme obesity [8]. However, this is mostly based on cross-sectional data [7][8][9]. A few longitudinal studies [10,11] have shown that FTO risk variants predispose individuals to weight gain from childhood until early adulthood, where further weight gain may occur.…”

Section: Introductionmentioning

confidence: 99%

The FTO gene is not associated with weight gain during six years of observation in the population of the PURE study in Poland

Zdrojowy-Wełna

Ramsey

Kolačkov

et al. 2020

Endokrynologia Polska

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Introduction: We present the first longitudinal study in Poland analysing the association between fat mass and obesity-associated gene (FTO) polymorphism and changes in anthropometric parameters. Material and methods: 1120 participants of the Prospective Urban Rural (PURE) study in Poland (mean age 53.7 years) were genotyped for FTO gene polymorphism (rs9939609, rs9930506, rs1421085, rs1121980). Anthropometric parameters were measured at three time points (baseline, after three years, and after six years of observation). Results: The mean body mass index (BMI) in the study group was 28 kg/m 2. Overall, there was a significant increase in the mean weight, BMI, and waist size during the six years (p ª 0). Although males initially weighed more than females (p = 0), over the whole six-year period women had a greater tendency to increase in weight (p = 0.068), BMI (p = 0.014), and waist size (p = 0.041). Subjects with at least one A allele at rs9939609 initially weighed more on average (77.5 vs. 74.7 kg, p = 0.027) and had a greater waist size (92 vs. 89.5 cm, p = 0.025) than those with the TT genotype. The differences in baseline results were more expressed in males than in females. There is no association between the changes in anthropometric parameters over the whole study period of six years and the FTO gene. Conclusions: FTO gene polymorphism is associated with anthropometric parameters in participants from the PURE study in Poland. However, there is no association between the presence of risk alleles and changes of anthropometric parameters over six years of observation.

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Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population

Cited by 10 publications

References 32 publications

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

FTO gene–lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population

The FTO gene is not associated with weight gain during six years of observation in the population of the PURE study in Poland

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