Genetic variants in selenoprotein genes modulate biomarkers of selenium status in response to Brazil nut supplementation (the SU.BRA.NUT study)

Donadio, Janaina L. S.; Rogero, Marcelo Macedo; Guerra-Shinohara, Elvira María; Barbosa, Fernando; Desmarchelier, Charles; Borel, Patrick; Sneddon, Alan Arthur; Hesketh, John E.; Cozzolino, Sílvia Maria Franciscato

doi:10.1016/j.clnu.2018.03.011

Cited by 22 publications

(38 citation statements)

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“…However, different from the variable associations of selenium with components of MetS, no significant association between rs7579 and a component of MetS was observed in our study. As both plasma levels of selenium and the rs7579 polymorphism take part in regulating the gene expression of SELENOP [15], selenium might be involved in the development of MetS partly through SELE-NOP, while the relation between selenium and components of MetS might be attributed to the effect of selenium independent of SELENOP.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, the downregulation of SELENOP expression improved systemic insulin sensitivity and glucose tolerance [14]. A previous study identified a single nucleotide polymorphism (SNP) located in the 3 ′ -untranslated region of the SELENOP gene, namely rs7579, which influenced both SELENOP mRNA expression and protein level [15]. Further studies provided evidence to correlate this SNP with metabolic factors; the SNP was associated with serum lipids and insulin sensitivity index [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Zhou

Luo

Yin

et al. 2020

Oxidative Medicine and Cellular Longevity

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The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine the associations of plasma selenium concentrations and selenoprotein P rs7579 polymorphism with MetS, a case-control study of 1279 MetS cases and 1279 sex- and age- (±2 years) matched controls was conducted based on the baseline data of the Tongji-Ezhou Cohort study. Plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry. MetS was defined using the definition of the Joint Interim Statement, adjusted for the Chinese population. In addition, the rs7579 polymorphism was genotyped by the Agena MassARRAY System. Plasma selenium concentrations in the MetS group were higher than in the control group (93.88 μg/L (83.17-107.41) vs. 92.66 μg/L (82.36-103.53), P<0.05). Compared with quartile 4 (≥103.53 μg/L), the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) associated with MetS were 0.79 (0.59-1.06) for quartile 1 (<82.36 μg/L), 0.75 (0.56-1.01) for quartile 2 (82.37-92.66 μg/L), and 0.61 (0.45-0.83) for quartile 3 (92.67-103.52 μg/L). The cubic spline analyses revealed a U-shaped association between plasma selenium and MetS, with the lowest risk at around 93.69 μg/L. Moreover, in cubic spline analyses, plasma selenium showed U-shaped associations with central obesity and high blood pressure, positive associations with hypertriglyceridemia and hyperglycemia, and a negative association with low high-density lipoprotein cholesterol. Additionally, both the GA and GA+AA genotype carriers were associated with increased ORs of MetS comparing with the GG genotype carriers. Our findings suggested a U-shaped association between plasma selenium and MetS and diverse associations between plasma selenium and components of MetS. Furthermore, our study found that the A allele of rs7579 was associated with higher odds of MetS. Further studies are needed to confirm our findings and elucidate the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Zhou

Luo

Yin

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Three years later, this same research group showed that supplementation with Brazil nuts (the main source of Se in the world) for 8 weeks in carriers of the C/C genotype (rs1050450) increased mRNA expression of the GPX1 gene ( p = 0.026), whereas that of the T allele did not change. Likewise, SELENOP mRNA expression was higher in carriers of the rare A allele for rs7579 before or after supplementation ( p =< 0.05) [ 74 ]. In addition, there are other studies that have reported similar results in relation to the concentration and activity of the GPx isoforms and SeP influenced by Se supplementation [ 75 , 76 ].…”

Section: Nutritional Selenium Status In Rheumatoid Arthritismentioning

confidence: 99%

The Relevance of Selenium Status in Rheumatoid Arthritis

Turrubiates-Hernández

Márquez‐Sandoval

González-Estévez

et al. 2020

Nutrients

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Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA.

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“…As anticipated given the function of SELENOP in selenium transport, there were associations between the SELENOP variants and the levels of several selenoproteins that require selenium for synthesis [50,51]. Among these were selenoproteins associated with protection from oxidative stress, a result supported by a cross-sectional study of oxidative stress markers among New Zealand men [52] and a study of individuals supplemented with selenium-rich Brazil nuts [53]. In addition to affecting the levels of SELENOP, these polymorphisms impacted the distribution between two SELENOP isoforms which differ by approximately 10 kDa [54].…”

Section: Selenium Transport Via Selenoprotein P (Selenop) and Selenopmentioning

confidence: 70%

The Interaction between Dietary Selenium Intake and Genetics in Determining Cancer Risk and Outcome

Kadkol

Diamond

2020

Nutrients

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There is considerable interest in the trace element selenium as a possible cancer chemopreventive dietary component, but supplementation trials have not indicated a clear benefit. Selenium is a critical component of selenium-containing proteins, or selenoproteins. Members of this protein family contain selenium in the form of selenocysteine. Selenocysteine is encoded by an in-frame UGA codon recognized as a selenocysteine codon by a regulatory element, the selenocysteine insertion sequence (SECIS), in the 3′-untranslated region of selenoprotein mRNAs. Epidemiological studies have implicated several selenoprotein genes in cancer risk or outcome based on associations between allelic variations and disease risk or mortality. These polymorphisms can be found in or near the SECIS or in the selenoprotein coding sequence. These variations both function to control protein synthesis and impact the efficiency of protein synthesis in response to the levels of available selenium. Thus, an individual’s genetic makeup and nutritional intake of selenium may interact to predispose them to acquiring cancer or affect cancer progression to lethality.

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Genetic variants in selenoprotein genes modulate biomarkers of selenium status in response to Brazil nut supplementation (the SU.BRA.NUT study)

Abstract: Genetic variations in GPX1 and SELENOP genes are associated with different responses of molecular and biochemical biomarkers of Se status after Brazil nut supplementation in healthy Brazilians. The SU.BRA.NUT study was registred at www.clinicaltrials.gov as NCT 03111355.

Cited by 22 publications

References 50 publications

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

The Relevance of Selenium Status in Rheumatoid Arthritis

The Interaction between Dietary Selenium Intake and Genetics in Determining Cancer Risk and Outcome

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