2011
DOI: 10.1038/nature10405
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Abstract: Blood pressure (BP) is a heritable trait1 influenced by multiple biological pathways and is responsive to environmental stimuli. Over one billion people worldwide have hypertension (BP ≥140 mm Hg systolic [SBP] or ≥90 mm Hg diastolic [DBP])2. Even small increments in BP are associated with increased risk of cardiovascular events3. This genome-wide association study of SBP and DBP, which used a multi-stage design in 200,000 individuals of European descent, identified 16 novel loci: six of these loci contain gen… Show more

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Cited by 1,784 publications
(1,168 citation statements)
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References 30 publications
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“…cGMP inhibits tubular sodium reabsorption in the proximal tubule, thick ascending limb of Henle's loop, and the collecting duct 38, 39, 43. Genetically modified mice lacking functional α 1 or β 1 sGC develop hypertension44 and genetic variants of the genes encoding for α 1 and β 1 sGC have been shown to be associated with elevated arterial pressure in humans 45. Furthermore, the antiangiogenic polypeptide endostatin has been shown to reduce the sGC protein abundance in cultured endothelial cells 46.…”
Section: Discussionmentioning
confidence: 99%
“…cGMP inhibits tubular sodium reabsorption in the proximal tubule, thick ascending limb of Henle's loop, and the collecting duct 38, 39, 43. Genetically modified mice lacking functional α 1 or β 1 sGC develop hypertension44 and genetic variants of the genes encoding for α 1 and β 1 sGC have been shown to be associated with elevated arterial pressure in humans 45. Furthermore, the antiangiogenic polypeptide endostatin has been shown to reduce the sGC protein abundance in cultured endothelial cells 46.…”
Section: Discussionmentioning
confidence: 99%
“…A score build on the cumulative effects of these loci displays a strong association with CAD (Levy et al , 2009; Newton‐Cheh et al , 2009; International Consortium for Blood Pressure Genome‐Wide Association Studies et al , 2011). Among the loci identified, there are several which are also genome‐wide significantly associated with CAD (Table 2, Fig 3B).…”
Section: Blood Pressurementioning
confidence: 99%
“…The common variant associated with CAD (rs7692387) is located in an intron however, and the exact mechanism from genotype to phenotype at this locus thus far remains elusive. Like NOS3 , the GUCY1A3 gene is also associated with blood pressure (International Consortium for Blood Pressure Genome‐Wide Association Studies et al , 2011). …”
Section: No/cgmp Signallingmentioning
confidence: 99%
“…Cardiovascular function is a complex trait attributable to multiple genetic and nongenetic factors 5, 6, 7, 8, 9, 10. To date, few studies have evaluated the role of the mitochondrial genome on cardiovascular functions such as blood pressure.…”
Section: Discussionmentioning
confidence: 99%
“…Genetic variants account for 19% to 56% of systolic blood pressure (SBP) variation,5 37% to 52% of diastolic blood pressure (DBP) variation,5 and up to 80% of mean arterial pressure (MAP) variation 6, 7. To date, however, the majority of genetic variants associated with blood pressure have been identified in the nuclear genome 8, 9, 10. In contrast, less is known regarding the relative contribution of the mitochondrial genome to blood pressure variation.…”
Section: Introductionmentioning
confidence: 99%