Genetic variants in glucocorticoid and mineralocorticoid receptors are associated with concentrations of plasma cortisol, muscle glycogen content, and meat quality traits in male Nellore cattle

Poleti, Mirele Daiana; DeRijk, Roel H.; Rosa, Alessandra Fernandes; Moncau, Cristina Tschorny; Oliveira, Paulo H.; Coutinho, Luiz Lehmann; Eler, Joanir Pereira; Balieiro, J. C. C.

doi:10.1016/j.domaniend.2014.12.004

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…It is difficult to establish a reference value for cortisol in response to pre-slaughter stress because there are many factors to be taken into account. The differences identified among breeds highlight the link between activation of the HPA axis by stressors and genetics [ 43 , 44 ], which includes temperament [ 45 , 46 , 47 ]. RE calves showed the highest cortisol value at slaughter time, and even though we have not measured “temperament” as a feature in this research, unlike the aforementioned authors [ 47 ] have, it is well-known that the RE breed has a wilder “temperament” than AV and RG breeds, a factor that could explain this finding.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Stress by Serum Biomarkers in Calves and Their Relationship to Ultimate pH as an Indicator of Meat Quality

García-Torres

Vaca

Tejerina

et al. 2021

Animals

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Seventy-eight calves from Asturiana de los Valles, Retinta, and Rubia Gallega breeds, under extensive and intensive farm systems and animal mixing and non-mixing conditions, and during the transport and lairage in slaughterhouses, were studied. This research aimed to study the effect of breed, farm system and mixing conditions on serum biomarkers (cortisol, lactate, glucose, serum amyloid A, haptoglobin, and C-reactive protein) and their relationship pHu at slaughter time, and to evaluate the response of the serum biomarkers of calves throughout fattening period. Moreover, this study aims to evaluate the response of the biomarkers in each breed during the fattening period. At slaughter time, cortisol and lactate were affected by BreedxFarm; Retinta showed the opposite pattern to the others and revealed the highest glucose in extensive farm systems. Rubia Gallega in mixing revealed the highest Amyloid A and haptoglobin. Extensive calves in mixing conditions showed the highest glucose. There was a relationship among the variables cortisol, lactate, Amyloid, and pHu. Slaughter time was a major stressor, and the stress response was mainly affected by breed. At slaughter, several biomarkers should be considered.

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Section: Resultsmentioning

confidence: 99%

Assessment of Stress by Serum Biomarkers in Calves and Their Relationship to Ultimate pH as an Indicator of Meat Quality

García-Torres

Vaca

Tejerina

et al. 2021

Animals

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“…This reversal effect suggested that glucocorticoids not only had anti-inflammatory effect, but also could enhance the expression of inflammatory cytokines ( Cox, 1995 ), recognized as a concentration dependent manner ( Munck et al, 1984 ). Previous studies considered that the reversal effect was related to the different affinities of glucocorticoid receptor and mineralocorticoid receptor to glucocorticoids, in which the mineralocorticoid receptor was characterized as high affinity and the glucocorticoid receptor as low affinity ( Baker et al, 2013 , Poleti et al, 2015 ). Glucocorticoids combined to mineralocorticoid receptor and played the pro-inflammatory role at low concentration, while glucocorticoids served as an anti-inflammatory character when combined with glucocorticoid receptor at high concentration.…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoids Regulate the Vascular Remodeling of Aortic Dissection Via the p38 MAPK-HSP27 Pathway Mediated by Soluble TNF-RII

et al. 2018

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Increasing researches suggest that inflammatory response is involved in vascular remodeling, which plays an important role in the development of aortic dissection. Glucocorticoids have been widely used in the clinical practice due to its powerful and effective anti-inflammatory property. However, the potential relationship between glucocorticoids and aortic dissection was still obscure. This study sought to elucidate the effect of glucocorticoids on the development and progression of aortic dissection, and the potential mechanism involved. Serum cortisol in aortic dissection patients was significantly higher than that in non-ruptured aortic aneurysm patients and healthy volunteers by radioimmunoassay. In modified C57BL/6 mouse model of aortic dissection, glucocorticoids reduced the incidence of aortic dissection and protected the collagen from degradation. Furthermore, glucocorticoids inhibited the TNF-α secretion of THP-1 monocytes, decreased the migration, phenotype switch from contractile type to synthetic type, and the apoptosis of human aortic smooth muscle cells induced by TNF-α. Finally, TNF-sRII was identified as an important cytokine in cellular interaction that participated in vascular remodeling by targeting the p38 MAPK-HSP27 pathway. These results indicate that glucocorticoids inhibit the incidence of aortic dissection by decreasing the TNF-α secretion and increasing the uncombined TNF-sRII, positively participating in vascular remodeling.

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“…Glucocorticoids (GCs), the end-hormones of the HPA axis, play a vital role in regulating glucose homeostasis [ 2 ]. Dexamethasone (Dex), a synthetic GC drug, is widely used as an anti-inflammatory and anti-allergic agent to treat various inflammatory, allergic and autoimmune diseases [ 3 , 4 ]. However, high doses or chronic use of GCs can produce undesired side effects, such as central obesity, hepatic hyperlipidemia, hypertension, glucose intolerance and muscular atrophy [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats

Niu

Hua

et al. 2018

J Animal Sci Biotechnol

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BackgroundDexamethasone (Dex), a synthetic glucocorticoid, is among the most commonly used drugs worldwide in animals and humans as an anti-inflammatory and immunosuppressive agent. GC has profound effects on plasma glucose level and other metabolic conditions. However, the effect of prolonged use of Dex on glucose metabolism in ruminants is still unclear.ResultsTen goats were randomly assigned to two groups: the control goats were injected with saline, and the Dex-treated goats were intramuscularly injected daily for 21 d with 0.2 mg/kg Dex. The results showed that plasma glucose and insulin concentrations were significantly increased after Dex administration (P < 0.05). Additionally, the content of hepatic glycogen was also markedly increased in Dex-treated goats (P < 0.01), while the content of glycogen in dorsal longissimus was unchanged by Dex (P > 0.05). The expression of several key genes, involved in blood glucose regulation, was detected by real-time PCR in the small intestine, skeletal muscle and liver. The expression of glucose transporter type 2 (GLUT2), sodium-glucose transporter 1 (SGLT1) and sodium-potassium ATPase (Na-K/ATPase) in the small intestine were generally increased by Dex, and GLUT2 mRNA expression was significantly up-regulated (P < 0.05). In liver, the expression of genes involved in gluconeogenesis including glucose-6-phosphatase catalytic subunit (G6PC), cytosolic form of phosphoenolpyruvate carboxykinase (PCK1) and pyruvate carboxylase (PC), were significantly down-regulated by Dex. However, the protein expression levels of PCK1 & PCK2 were significantly increased by Dex, suggesting a post-transcriptional regulation. In dorsal longissimus, the mRNA expression of genes associated with gluconeogenesis and the insulin signaling pathway were generally up-regulated by Dex, but the mRNA expression of two markers of muscle atrophy, namely F-box protein 32 (FBXO32/Atrogin1) and muscle RING-finger protein 1 (MuRF1), was not altered by Dex.ConclusionsTaken together, these results indicate that chronic administration of a low dosage of Dex induces hyperglycemia mainly through gluconeogenesis activation in the goat liver.

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Genetic variants in glucocorticoid and mineralocorticoid receptors are associated with concentrations of plasma cortisol, muscle glycogen content, and meat quality traits in male Nellore cattle

Cited by 9 publications

References 37 publications

Assessment of Stress by Serum Biomarkers in Calves and Their Relationship to Ultimate pH as an Indicator of Meat Quality

Assessment of Stress by Serum Biomarkers in Calves and Their Relationship to Ultimate pH as an Indicator of Meat Quality

Glucocorticoids Regulate the Vascular Remodeling of Aortic Dissection Via the p38 MAPK-HSP27 Pathway Mediated by Soluble TNF-RII

Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats

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