Infectious Disease Clinics of North America volume 22, issue 4, P741-753 2008 DOI: 10.1016/j.idc.2008.05.004 View full text
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Katherine P. Himes, Hyagriv N. Simhan

Abstract: Preterm birth is a heterogeneous disorder that is responsible for significant neonatal morbidity and mortality. Intrauterine infection is implicated in a significant proportion of preterm birth-particularly in early gestation. Epidemiologic evidence supports a genetic component to infection overall and preterm birth in particular. Furthermore, a number of studies examining genes involved in pathogen recognition and our response to pathogens suggest a genetic susceptibility to infection-mediated preterm birth. …

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