Genetic Regulation of Morphogenesis of Drosophila melanogaster Mechanoreceptors

Furman, D. P.; Бухарина, Т. А.

doi:10.1134/s1062360422040038

Cited by 1 publication

(4 citation statements)

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“…This result indirectly confirms the earlier assumption that a delayed appearance of the PHYL protein is the particular necessary condition for parent cell determination (Furman, Bukharina, 2022).…”

Section: Modeling Of Crc Operation In the Presumptive Parental Cell O...supporting

confidence: 88%

“…The GNs "Neurogenesis:prepattern", "Neurogenesis:deter mination", and "Neurogenesis:asymmetric division", which we have earlier reconstructed are examples of the networks responsible for the development of ordered structures during ontogenesis. Together, these GNs provide a definite composi tion of mechanoreceptors (sensory organs of the peripheral nervous system) on the head and body of drosophila (Furman, Bukharina, 2022). Analysis of these networks has elicited the most important connecting link that controls their operation, namely, central regulatory circuit (CRC).…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of these networks has elicited the most important connecting link that controls their operation, namely, central regulatory circuit (CRC). It is a correct CRC operation in the "Neurogenesis:determination" GN that de termines the implementation of the key event in the morpho genesis of each mechanoreceptor -the definition of a single sensory organ parental cell (SOPC), which is separated within a proneural cluster, the group of epidermal cells within imagi nal disk (Furman, Bukharina, 2022). The parental cell differs from the surrounding ones by the content of proneural ASC proteins, coded for by the gene complex of the same name, achaete-scute complex or AS-C (Reeves, Posakony, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…An increased ASC content is the factor that determines the neural fate of a cell. By ensuring the development of both individual mechanoreceptors and their overall array, the socalled bristle pattern, the CRC regulates the production of these proteins to the level necessary for a cell to acquire an SOPC status (Furman, Bukharina, 2022).…”

Section: Introductionmentioning

confidence: 99%

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The central regulatory circuit in the gene network controlling the morphogenesis of Drosophila mechanoreceptors: an <i>in silico</i> analysis

Bukharina,

Golubyatnikov,

Furman

2023

Vestn. VOGiS

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Identification of the mechanisms underlying the genetic control of spatial structure formation is among the relevant tasks of developmental biology. Both experimental and theoretical approaches and methods are used for this purpose, including gene network methodology, as well as mathematical and computer modeling. Reconstruction and analysis of the gene networks that provide the formation of traits allow us to integrate the existing experimental data and to identify the key links and intra-network connections that ensure the function of networks. Mathematical and computer modeling is used to obtain the dynamic characteristics of the studied systems and to predict their state and behavior. An example of the spatial morphological structure is the Drosophila bristle pattern with a strictly defined arrangement of its components – mechanoreceptors (external sensory organs) – on the head and body. The mechanoreceptor develops from a single sensory organ parental cell (SOPC), which is isolated from the ectoderm cells of the imaginal disk. It is distinguished from its surroundings by the highest content of proneural proteins (ASC), the products of the achaete-scute proneural gene complex (AS-C). The SOPC status is determined by the gene network we previously reconstructed and the AS-C is the key component of this network. AS-C activity is controlled by its subnetwork – the central regulatory circuit (CRC) comprising seven genes: AS-C, hairy, senseless (sens), charlatan (chn), scratch (scrt), phyllopod (phyl), and extramacrochaete (emc), as well as their respective proteins. In addition, the CRC includes the accessory proteins Daughterless (DA), Groucho (GRO), Ubiquitin (UB), and Seven-in-absentia (SINA). The paper describes the results of computer modeling of different CRC operation modes. As is shown, a cell is determined as an SOPC when the ASC content increases approximately 2.5-fold relative to the level in the surrounding cells. The hierarchy of the effects of mutations in the CRC genes on the dynamics of ASC protein accumulation is clarified. AS-C as the main CRC component is the most significant. The mutations that decrease the ASC content by more than 40 % lead to the prohibition of SOPC segregation.

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Section: Modeling Of Crc Operation In the Presumptive Parental Cell O...supporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%