Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population

Liu, Di; Wang, Meng; Tian, Tian; Wang, Xijing; Kang, Huafeng; Jin, Tianbo; Zhang, Shu-Qun; Guan, Heng; Yang, Pengfei; Liu, Kang; Liu, Xinghan; Xu, Peng; Zheng, Yi; Dai, Zhijun

doi:10.18632/aging.101177

Cited by 26 publications

(28 citation statements)

References 33 publications

(40 reference statements)

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“…Frequencies of the variants were estimated using the Hardy–Weinberg equilibrium (HWE) ( p value calculated by exact test) to compare the expected frequencies of the genotypes in the control groups. PLINK software (http://pngu.mgh.harvard.edu/purcell/plink/) were used to calculate the 95% confidence intervals (CIs) and odds ratios (ORs) by unconditional logistic regression analysis with adjustment for age and gender (Lin et al, ), in order to assess the strength for the association of genotypes and their combinations with GC risk in the four models (codominant, dominant, recessive, and log‐additive) (Jin et al, ; Lin et al, ; Liu et al, ). Finally, we measured the linkage disequilibrium (LD) between loci, haplotype construction, and genetic association was calculated by unconditional logistic regression.…”

Section: Methodsmentioning

confidence: 99%

Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case–control study

Niu

et al. 2019

Mol Genet Genomic Med

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Background Gastric cancer (GC), the second leading cause of cancer mortality behind lung cancer worldwide, is caused by both genetic and environmental factors. In this study, we evaluated the association between the genetic polymorphisms of methylenetetrahydrofolate reductase ( MTHFR ), methionine synthesis reductase ( MTR ), and methyltransferase reductase ( MTRR ) genes and ischemic stroke risk in Chinese population. Methods A case–control study was conducted including 681 patients with GC and 756 healthy controls. Chi‐squared test/Fisher's exact test and genetic model were used to evaluate associations. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression. Results In the allele model, using the chi‐square test, we found that the rs1532268 in MTRR with a minor allele T was significantly associated with increased risk of GC (OR = 1.24, 95% CI, 1.00–1.53; p = 0.048). In the genetic model analysis, we identified that the single‐nucleotide polymorphism of the rs1801133 in MTHFR could increase the GC risk in the recessive model (OR = 1.31, 95% CI, 1.01–1.70; p = 0.042) and log‐additive model (OR = 1.19, 95% CI, 1.02–1.38; p = 0.025). In MTHFR , a strong linkage of rs2274976 and rs1801133 was detected. The haplotype “GC” in the MTHFR gene was found to prominently increase the risk of GC (OR = 1.26, 95% CI: 1.07–1.47; p = 0.005). Other haplotypes did not display the correlativity. Conclusion This study suggested that MTR and MTHFR polymorphisms may contribute to increase the risk of GC.

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Section: Methodsmentioning

confidence: 99%

Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case–control study

Niu

et al. 2019

Mol Genet Genomic Med

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“…Moreover, the A allele of rs3761548 was associated with a larger size of tumor and more likely to have overexpression of HER2 , which means that this locus might help to guide treatment for BC and be a potential biomarker for classification of tumor subtype. In another Chinese population, Di et al reported that rs28366003 and rs10636 polymorphisms in MT2A had a correlation with BC risk; moreover, the relationship between this polymorphism and the histological grade might help us to judge tumor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

et al. 2019

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BackgroundPrevious studies have revealed that the single nucleotide polymorphism (SNP) rs2188380 was identified as a novel locus of gout. Interestingly, gout resulting from high serum uric acid (SUA) was also identified to be associated with the risk of breast cancer (BC). We hypothesized that maybe there was a relationship between rs2188380 and the risk of BC. Therefore, our study was conducted to investigate whether this novel gout‐related SNP (rs2188380) was associated with BC risk as well as the clinical and pathological characteristics in the southwest Chinese population.Materials and methodsWe performed a case‐control study including 104 breast cancer patients and 112 healthy controls to investigate whether rs2188380 is associated with BC risk in the southwest Chinese population. The genotyping was performed by the SNP scan method. General characteristics and clinicopathological characteristics of tumors were also included in the analysis. The statistical evaluations were performed using the Student t test, the chi‐square test or Fisher's exact test, and unconditional logistic regression analysis.ResultsThe C/C genotype of rs2188380 might be related to BC risk to some extent compared with G/G genotype (OR = 9.241, 95% CI = 1.122‐76.101, P = 0.039). Furthermore, after adjusting the age, the association still existed (OR = 8.788, 95% CI = 1.063‐72.636, P = 0.044). However, no significant association was observed between rs2188380 and the clinicopathological characteristics of BC.ConclusionsOur study primarily indicated that rs2188380 might have a potential association with BC risk to some extent. With a limited sample size and statistical power, further studies based on larger populations are needed to confirm the association.

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“…The genotyping of the 11 SNPs was carried out on the MassARRAY iPLEX (Agena Bioscience, San Diego, CA, USA) platform using the matrix‐assisted laser desorption ionization‐time of flight (MALDITOF) (Lin et al, ; Liu, Wang, et al, ; Wang et al, ). Genotyping results were output by Agena Bioscience TYPER version 4.0 software.…”

Section: Methodsmentioning

confidence: 99%

The influence of ACYP2 polymorphisms on gastrointestinal cancer susceptibility in the Chinese Han population

Duan

Hong

Wang

et al. 2019

Molec Gen & Gen Med

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Background Gastrointestinal cancer (GI cancer) is a type of cancer that has a high death rate. It has been reported that ACYP2 gene was associated with the development of gastric cancer and colorectal cancer, but it is not clear that the relationship between ACYP2 gene and GI cancer in Chinese Han population. This study aimed to investigate the association between polymorphisms of ACYP2 and GI cancer in the Chinese Han population. Methods We used Agena MassARRAY to determine the genotypes of 1,160 GI cancer patients and 495 healthy controls. The correlation between ACYP2 variants and GI cancer risk was examined by logistic regression analysis. Results We identified that rs6713088 (OR = 1.17, 95% CI: 1.00–1.36, p = 0.047), rs843711 (OR = 1.17, 95 CI: 1.01–1.36, p = 0.035), and rs11896604 (OR = 1.20, 95% CI: 1.00–1.45, p = 0.048) were correlated with an increased risk of GI cancer under allele model. Rs11125529 under the recessive model (OR = 2.05, 95% CI: 1.00–4.23, p = 0.038), rs843711 in recessive model (OR = 1.37, 95% CI: 1.04–1.82, p = 0.026), and rs11896604 under log‐additive model (OR = 1.23, 95% CI: 1.01–1.51, p = 0.042) were associated with an increased risk of GI cancer. Conclusion Our study suggested that polymorphisms of ACYP2 gene might be associated with susceptibility to GI cancer.

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Genetic polymorphisms (rs10636 and rs28366003) in metallothionein 2A increase breast cancer risk in Chinese Han population

Cited by 26 publications

References 33 publications

Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case–control study

Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case–control study

Association between rs2188380 and the risk of breast cancer in southwest Chinese population

The influence of ACYP2 polymorphisms on gastrointestinal cancer susceptibility in the Chinese Han population

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