Genetic polymorphisms of interleukin 20 (IL-20) in patients with ulcerative colitis

Yamamoto-Furusho, Jesús K.; De-León-Rendón, Jorge L.; Torre, Monica García de la; Álvarez-León, Edith; Vargas‐Alarcón, Gilberto

doi:10.1016/j.imlet.2012.11.008

Cited by 16 publications

(8 citation statements)

References 28 publications

(36 reference statements)

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“…However, the IL20 rs2981573 genetic variant has been reported to be associated with several inflammatory diseases. The minor allele frequency was found to be lower than that of healthy controls in patients with ulcerative colitis in a Mexican population [30], in patients with recurrent wheeze after respiratory syncytial bronchiolitis in a Dutch population [10], and in patients with palmoplantar pustulosis in an Estonian (Caucasian) population [31].…”

Section: Discussionmentioning

confidence: 82%

The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock

et al. 2018

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Background: The IL10 family of genes includes crucial immune regulators.We tested the hypothesis that single nucleotide polymorphisms (SNPs) in IL10, IL19, IL20, and IL24 of the IL10 family gene cluster alter the clinical outcome of septic shock. Methods: Patients with septic shock (n = 1,193) were genotyped for 13 tag SNPs of IL10, IL19, IL20, and IL24. IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped for IL20 rs2981573 A/G. The primary outcome variable was 28-day mortality. Results: Patients with the G allele of IL20 rs2981573 had a significantly increased hazard of death over the 28-day period compared to patients with the A allele in the septic shock cohort (adjusted hazard ratio 1.27; 95% confidence interval 1.10-1.47; p = 8.0 × 10^-4). Patients with the GG genotype had more organ dysfunction (p < 0.05). The GG genotype was associated with increased IL20 gene expression in stimulated lymphoblastoid cells in vitro (p < 0.05). The cardiac surgical ICU patients with the GG genotype had an increased length of ICU stay (p = 0.032). Conclusions: The GG genotype of IL20 rs2981573 SNP was associated with increased IL20 gene expression and increased adverse outcomes in patients with septic shock and following cardiac surgery.

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Section: Discussionmentioning

confidence: 82%

The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock

et al. 2018

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“…It was found that IL20 cytokine has been involved in the developing of atherosclerosis [15,17], however, at the present, there are not studies that analyzed the association of the polymorphisms located in the gene that encodes this cytokine with the presence of atherosclerosis. The association of these polymorphisms with some inflammatory diseases has been reported, specifically in psoriasis and ulcerative colitis [28,29]. In African Americans, the rs1400986 and rs1518108 polymorphisms were associated with chronic hepatitis B infection [16].…”

Section: Discussionmentioning

confidence: 99%

Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

et al. 2020

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Inflammation has been involved in the development of atherosclerosis, type 2 diabetes mellitus, insulin resistance, and obesity. Interleukin 20 is a pro-inflammatory cytokine encoded by a polymorphic gene located in chromosome 1. The aim of the study was to evaluate the association of two IL-20 polymorphisms (rs1400986 and rs1518108) with subclinical atherosclerosis (SA), cardiovascular risk factors and IL-20 levels in a cohort of Mexican individuals. The polymorphisms were determined in 274 individuals with SA and 672 controls. Under different models, rs1400986 (OR = 0.51, Pcodominant1 = 0.0001; OR = 0.36, Pcodominant2 = 0.014; OR = 0.49, Pdominant = 0.0001 and OR = 0.55, Padditive = 0.0001) and rs1518108 (OR = 0.62, Pcodominant2 = 0.048 and OR = 0.79, Padditive = 0.048) were associated with a lower risk of SA. These polymorphisms were associated with cardiovascular risk factors in individuals with SA and controls. Controls with the rs1400986 TT genotype presented high levels of IL-20 (p = 0.031). In individuals with the rs1400986 CC genotype, we observed a negative correlation between IL-20 levels and total abdominal tissue (TAT), visceral abdominal tissue (VAT) and subcutaneous abdominal tissue (SAT). Our results indicate that the IL-20 rs1400986 and rs1518108 polymorphisms were associated with decreased risk of developing SA and with some cardiovascular risk factors in individuals with SA and healthy controls. Negative correlation between BMI and VAT/SAT ratio in individuals with rs1400986 CC genotype and among IL-20 levels and TAT, VAT and SAT was observed.

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“…A case–control study in a Korean population suggested that the −1920 G > A polymorphism in IFITM1 may be associated with susceptibility to UC ( P = 0.002) [ 28 ]. A case–control study in a group of 198 Mexican Mestizo patients with UC and 698 ethnically matched healthy unrelated individuals with no family history of UC suggested that the GG genotypes of the IL-20 polymorphisms (rs2981573 and rs2232360) might have an important role in the development of UC ( P = 0.017) in the Mexican population [ 29 ]. A case–control study in 56 patients with UC and 50 healthy controls suggested that the IL-10 −819 CC was a candidate genotype for both IBS ( P = 0.047) and UC ( P = 0.007) in Japanese [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Association of the interleukin-22 genetic polymorphisms with ulcerative colitis

Chi

Zheng

et al. 2014

Diagn Pathol

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BackgroundInterleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (−429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.MethodsThis hospital-based case–control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5′ exonuclease assays (TaqMan).ResultsPatients with UC had a significantly higher frequency of IL-22 −429 TT genotype [odds ratio (OR) =2.43, 95% confidence interval (CI) = 1.35, 4.37; P = 0.003] and −429 T allele (OR =1.54, 95% CI = 1.14, 2.07; P = 0.004) than controls. The findings are still emphatic by the Bonferroni correction. The IL-22 +1046 T/A and IL-22 +1995 A/C gene polymorphisms were not associated with a risk of UC. When stratifying by clinical type, location and disease severity of UC, no significant differences were found in any groups.ConclusionThis is the first study to provide evidence for an association of IL-22 −429 C/T gene polymorphisms with UC risk. Additional well-designed large studies were required for the validation of our results.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_183

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Genetic polymorphisms of interleukin 20 (IL-20) in patients with ulcerative colitis

Cited by 16 publications

References 28 publications

The<b><i> IL20</i></b> Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock

The<b><i> IL20</i></b> Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock

Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study

Association of the interleukin-22 genetic polymorphisms with ulcerative colitis

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