Genetic polymorphisms in neuroendocrine disorder-related candidate genes associated with pre-pregnancy obesity in gestational diabetes mellitus patients by using a stratification approach

Abstract

Background: Certain candidate genes have been associated with obesity. The goal of this study is to determine the association between thirteen neuroendocrine disorder-related candidate genes and prepregnancy obesity among gestational diabetes mellitus (GDM) patients using the stratification approach defined the Asian and International criteria-based body mass index (BMI).Methods: This was a post-hoc case-control exploratory sub-analysis of a cross-sectional study among GDM women to determine which candidate single nucleotide polymorphisms (SNPs) related to neuroendocrine disorders may be associated with obesity. Factors were adjusted for socio-demographic characteristics and concurrent medical problems in this particular population. Pre-pregnancy BMI and concurrent medical profiles were obtained from maternal health records. Obesity is defined as BMI of ≥27.5 kg/m 2 for Asian criteria-based BMI and >30 kg/m 2 for International criteria-based BMI. Thirteen candidate genes were genotyped using Agena ® MassARRAY and examined for association with pre-pregnancy obesity using multiple logistic regression analysis. The significant difference threshold was set at P value <0.05.Results: Three hundred and twelve GDM women were included in this study; 60.9% and 44.2% of GDM patients were obese using Asian and International criteria-based BMI, respectively. GDM patients with AA or AG genotypes in specific SNP of brain-derived neurotrophic factor (BDNF) (G > A in rs6265) are more likely to be obese (adjusted odd ratio =2.209, 95% CI, 1.305, 3.739, P=0.003) compared to those who carry the GG genotype in the SNP adjusted for parity, underlying with asthma, heart disease, anaemia, education background in the International criteria-based BMI stratification group. On the other hand, there were no associations between other candidate genes (NRG1,

A Comparative Full-Length Transcriptome Analysis Using Oxford Nanopore Technologies (ONT) in Four Tissues of Bovine Origin

“…Additionally, 32 transcripts were identified for TEX51 . A study of the genetic association between obesity and the TEX51 [ 55 , 56 ] neuroendocrine disorder-related candidate gene suggested a lack of any correlation between TEX51 and maternal obesity and reported that the highest number of transcripts of any TEX was recorded for TEX51 , indicating the potentially critical function of this gene in male cattle reproductively. Hence, in-depth functional studies are warranted in the future.…”

Association Association of genetic variant of OXTR (rs53576) and MTNR-1B (rs10830963 and rs1387153) with symptoms of stress in Pakistani women with Gestational Diabetes.

“…Many environmental, nutritional and genetic factors are related to the development of GDM, which potentiates the stress condition/ symptomatology of pregnancy. Among the genetic factors, OXTR & MNTR1B single nucleotide polymorphisms (SNPs) have been of particular focus 22 . Although, there are studies that found an association between OXTR & MNTR1B SNPs gestational diabetes while other studies documented involvement of OXTR & MNTR1B SNPs in psychological disorders like depression, anxiety and/or stress we could not find out studies in our population which have evaluated the association of the above given genetic risk factors with stress development in GDM.…”