Genetic Polymorphism of VEGF-1154 (A/G) in Laryngeal Squamous Cell Carcinoma

Unal, Zeynep Nil; Ünal, Murat; Bagdatoglu, Ozlen; Polat, Gürbüz; Atik, Uğur

doi:10.1016/j.arcmed.2007.09.008

Cited by 14 publications

(10 citation statements)

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“…VEGF signaling induces the proliferation, differentiation, and migration of vascular endothelial cells; increases the permeability of the capillaries, and enhances the survival of endothelial cells by preventing their apoptosis. In multiple studies, overexpression of VEGF in HNSCC was associated with metastasis, recurrence, and poor prognosis …”

Section: Discussionmentioning

confidence: 99%

Molecular profiling of sinonasal undifferentiated carcinoma

et al. 2013

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Background Sinonasal undifferentiated carcinoma remains a poorly characterized malignancy at both the clinical and molecular level, and consequently the optimal treatment strategy remains undefined. Methods We utilized a mass spectroscopy-based approach (Sequenom™) to evaluate 95 hallmark single nucleotide variations within 12 oncogenes or tumor suppressor genes (AKT, BRAF, CDK4, Beta-catenin, EGFR, FBXW7, JAK2, c-KIT, KRAS, PDGFR, PI3K, VEGF) in 13 histologically confirmed SNUC cases. Results None of the samples demonstrated activating mutations in any of the 95 SNVs. Conclusions Select clinically relevant activating genomic mutations were not identified the 13 patient samples. However, polymorphisms were noted within the promoter region of VEGF. These may merit future study as predictive biomarkers for treatment response or overall survival. Additionally, future studies focusing on larger tumor sets and utilizing whole genome or exome sequencing may help define genetic aberrations in SNUC that can be clinically targeted with available or emerging biological agents.

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Section: Discussionmentioning

confidence: 99%

Molecular profiling of sinonasal undifferentiated carcinoma

et al. 2013

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“…Many case control studies concerning VEGF –1154G > A were also conducted in various kinds of carcinomas, with the same ambiguous outcomes noted for the two SNPs discussed above. ( 27,28,30 ) A significant association between the A allele and low serum VEGF levels in Crohn's disease patients has been reported, ( 27 ) and the –1154AA genotype is associated with low VEGF expression in resected NSCLC patients. ( 29 ) However, there are no reports concerning the prognostic value of the VEGF –1154G > A genotype.…”

Section: Discussionmentioning

confidence: 99%

Effect of vascular endothelial growth factor polymorphisms on survival in advanced‐stage non‐small‐cell lung cancer

Masago¹,

Fujita²,

Kim³

et al. 2009

Cancer Science

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Polymorphisms have been identified in the vascular endothelial growth factor (VEGF) gene that may affect VEGF production. We hypothesized that such polymorphisms may correlate with survival outcomes among advanced-stage non-small-cell lung cancer (NSCLC) patients. We evaluated the association between VEGF polymorphisms and overall survival among patients with advanced NSCLC who were treated with at least one cytotoxic regimen at

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“…Ku et al (21) reported the association between -460T/T VEGF genotype and oral cancer, Yapijakis et al (22) showed an elevated frequency of heterozygotes with the +936C/T polymorphism and oral cancer, and Cheng et al (24) identified an association between +960C/C VEGF genotype and vascular invasion in oral squamous cell carcinoma. Nasr et al (25) reported an association between carriers of VEGF -2578C allele polymorphism and aggressiveness of the tumor in nasopharyngeal carcinoma and Ünal et al (26) showed an association between the VEGF -1154G/G genotype and larynx cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, Unal et al (26) hypothesized that patients with high expression of the VEGF genotype have more aggressive and metastatic tumor behavior than low expression or heterozygote genotypes.…”

Section: Discussionmentioning

confidence: 99%

“…In the -1154G/A polymorphism of the VEGF gene, the -1154G/G genotype of the VEGF gene appears to increase the risk for laryngeal squamous cell carcinoma (26). The polymorphism -1154G/A VEGF has been shown to be associated with differential expression of VEGF in vitro and has been implicated in the risk for several types of tumors and other diseases with putative angiogenic components.…”

Section: Introductionmentioning

confidence: 99%

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