Genetic Polymorphism of Microsomal Epoxide Hydrolase Enzyme Gene in Preeclamptic Females

KAMAL, M.; El-Saadany, Zainab Ali; Fouad, Nevien; Elaal, Asmaa Ahmed A.; Makhlouf, Manal Mohamed; Shabaan, Mona; Elrahman, Dalia Roshdi A.

doi:10.1097/maj.0b013e31822be635

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…These findings are in agreement with Song et al [3] who reported similar frequencies for CXCR5 rs6421571 C/T and that the mutant (T) allele conferred a 1.6-fold increased risk of NHL including DLBCL. In studies on the risk of developing other cancers, the rs6421571 T haplotype was associated with an increased susceptibility of 1.7-fold to colorectal cancer and 1.2-fold to Crohn's disease [15,16]. Regarding the CXCR5 rs78440425 G/A SNP, heterozygous (GA), homozygous (GG), both mutants (GA and GG), and also the G allele frequency, were all higher in the DLBCL patients than in controls, although the difference did not achieve statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma

et al. 2020

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Background: The chemokine receptor CXCR5 is selectively expressed on B cells; it is involved in lymphocyte homing and the development of normal lymphoid tissue. Its principle ligand is CXCL13 or B lymphocyte chemoattractant. Three polymorphisms in the CXCR5 gene, rs148351692 C/G, rs6421571 C/T, and rs78440425 G/A, have been identified. Objective: To assess the genetic polymorphisms of CXCR5 and evaluate their possible contribution to the susceptibility and response to therapy of diffuse large B-cell lymphoma (DLBCL). Patients and Methods: Fifty DLBCL (not otherwise specified) patients and 50 control subjects were included in this study. CXCR5 genotypes were determined by PCR-RFLP. Results: Our study revealed that the CXCR5 rs148351692 C/G and rs6421571 C/T gene polymorphisms are associated with an increased risk of developing DLBCL (OR 28.57 [95% CI 8.96–96.56] and 3.45 [1.67–11.83] respectively), while CXCR5 rs78440425 G/A showed no association with the risk of lymphoma. Moreover, the double and triple combined gene polymorphisms are associated with an increased risk of developing DLBCL of approximately 120-fold and 105-fold, respectively. CXCR5 gene polymorphisms had no significant impact on disease outcome or response to therapy. Conclusions: CXCR5 gene polymorphisms could be considered a potential risk factor for the development of DLBCL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma

et al. 2020

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“…[ 12 ] In contrast, other association studies revealed a positive association between these two SNPs and PE risk. [ 7 13 14 ]…”

Section: Discussionmentioning

confidence: 99%

Association of four missense SNPs with preeclampsia in Saudi women

Aljuaid

Muharram

Loqtum

et al. 2020

Saudi J Med Med Sci

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Objective: The objective of this study was to investigate the association of rs1051740, rs2234922 (in microsomal epoxide hydrolase 1; EPHX1 ), rs268 (in lipoprotein lipase; LPL ) and rs6025 (in Factor V Leiden; F5 ) genetic variants with the risk of preeclampsia development in Saudi women. Materials and Methods: This case–control study recruited 233 Saudi women (94 preeclampsia cases and 139 healthy controls) who visited the Gynecology and Obstetrics Departments of two hospitals in Jeddah, Saudi Arabia, for routine postpregnancy clinical follow-ups. All the women underwent thorough clinical and biochemical investigations conducted according to the standard clinical guidelines. Genotyping of the study participants was done using real-time polymerase chain reaction-based TaqMan allelic discrimination assay. The strength of the association between genetic variants and disease development was assessed using chi-square, odds ratio, 95% confidence interval and multifactor dimensionality reduction tests. Result: The minor alleles “G” in rs268 ( LPL ) and “A” in rs6025 ( F5 ) were absent in Saudi women. The frequencies of rs1051740 and rs2234922 of EPHX1 , both in the homozygous and allelic forms, were not significantly different between preeclampsia patients and healthy controls (for all tests, P > 0.05). The multifactor dimensionality reduction analysis also indicated that the interaction between the four studied single-nucleotide polymorphisms (SNPs) had no significant association with preeclampsia risk. Conclusion: This study found that none of the studied genetic variants (neither the single SNP nor the SNP–SNP interactions) explain the development of preeclampsia in the Saudi population. These findings not only underscore the disease heterogeneity but also highlight the need to develop population-specific diagnostic genetic biomarkers for preeclampsia.

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“…La segunda variante es caracterizada por la sustitución de C por A en el exón 4 causando His139Arg, relacionado con el incremento del 25% de la actividad de la enzima. Por lo anterior se puede clasificar la actividad de esta enzima en baja, intermedia y alta, dependiendo de la presencia o ausencia del polimorfismo, asocián-dose a la patogénesis de la preeclampsia (50).…”

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Preeclampsia: la evolución diagnóstica desde la genómica y la proteómica

Cotes

Sánchez

Grisales

et al. 2013

Rev. chil. obstet. ginecol.

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RESUMENLa preeclampsia se define como la presencia de hipertensión arterial evidenciada con dos lecturas de presión arterial ≥140/90 (presión arterial sistólica≥ 140 mmHg o diastólica≥90 mmHg) y proteinuria superior a 0,3 g/día después de la vigésima semana de embarazo en pacientes anteriormente normotensas. Aún se desconoce la verdadera causa, aunque existen algunas teorías que indican que la combinación de varios factores ambientales, genéticos e inmunológicos puede aumentar la susceptibilidad. La genómica y proteó-mica han venido proporcionando herramientas para la comprensión y diagnóstico de nuevos biomarcadores que apunten hacia novedosos avances en el diagnóstico, la prevención y el tratamiento de dicha patología.PALABRAS CLAVE: Preeclampsia, genómica, proteómica SUMMARY Preeclampsia was defined as the presence of hypertension evidenced two blood pressure readings ≥140/90 (systolic blood pressure ≥140 mmHg or diastolic ≥90 mmHg) and proteinuria greater than 0.3 g/day after the twentieth week pregnancy in previously normotensive patients. Still the real cause is unknown, although there are some theories that suggest that a combination of environmental factors, genetic and immunological may increase susceptibility. Genomics and proteomics have been providing necessary progress in the understanding and diagnosis of new biomarkers that point to novel advances in the diagnosis, prevention and treatment of this disease. KEY WORDS: Preeclampsia, genomics, proteomics INTRODUCCIÓNLa preeclampsia (PE) es una patología asociada a población gestante con una alta incidencia en el mundo. Es importante evaluar la influencia de condicionantes externos y la intervención médica, para promover medidas de acción saludables que favorezcan el mejoramiento en la calidad de vida de las pacientes. Una intervención temprana que detecte la enfermedad oportunamente, es la base para reducir las estadísticas de mortalidad.Las muertes generadas por PE siguen un patrón común en cuanto a su aparición, desarrollo y en su gran mayoría evitables, siempre y cuando se 148 REV CHIL OBSTET GINECOL 2013; 78(2): 148 -153

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Genetic Polymorphism of Microsomal Epoxide Hydrolase Enzyme Gene in Preeclamptic Females

Cited by 9 publications

References 16 publications

CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma

CXC Chemokine Receptor Type 5 Gene Polymorphisms in a Cohort of Egyptian Patients with Diffuse Large B-Cell Lymphoma

Association of four missense SNPs with preeclampsia in Saudi women

Preeclampsia: la evolución diagnóstica desde la genómica y la proteómica

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